Jag1 binds Notch2

Stable Identifier
R-MMU-2032378
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Jag1 binds Notch2
Mouse Jag1, exogenously expressed on the surface of Chinese hamster ovary (CHO) cells, binds Notch2, a predominant Notch protein on the surface of mouse BaF3 cells, inducing Notch2 cleavage and translocation of Notch2 intracellular domain (NICD2) to the nucleus.
Literature References
PubMed ID Title Journal Year
10958687 Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

Shimizu, K, Chiba, S, Hosoya, N, Kumano, K, Saito, T, Kurokawa, M, Kanda, Y, Hamada, Y, Hirai, H

Mol Cell Biol 2000
Participants
Input
Output
Entity On Other Cell
Orthologous Events
JAG1 binds NOTCH2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Haw, R  (2013-01-14)
Boyle, S  (2013-04-25)
Ilagan, MXG  (2013-04-25)
Created
Orlic-Milacic, M  (2012-01-06)
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