Reactome | DUSP7 [nucleoplasm]

DUSP7 [nucleoplasm]

Stable Identifier

R-MMU-203791

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q91Z46

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK1 (TRKA) (Mus musculus)
      - Nuclear Events (kinase and transcription factor activation) (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        DUSP7 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91Z46

Reference Genes

BioGPS Gene:235584

ENSEMBL:ENSMUSG00000053716

ENSEMBL:ENSMUSG00000053716.10

KEGG Gene (Mus musculus):235584

Monarch:235584

NCBI Gene:235584

UCSC:Q91Z46

Reference Transcript

RefSeq:NM_153459.4

Other Identifiers

10588495

108056_at

1427416_x_at

1452097_a_at

1460393_a_at

17521194

235584

4307891

4354604

4454762

4584710

4593997

4836605

4868383

5070124

5148285

5200073

5331846

5559967

5616397

A_52_P173197

A_55_P1993836

GE136828

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005737

GO:0005829

GO:0006470

GO:0008138

GO:0008330

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0017018

GO:0023052

GO:0033550

GO:0036211

GO:0043409

GO:0140096

ILMN_2691548

ILMN_2804523

Msa.16748.0_s_at

mMC025770

Participates

as a member of

ERK-specific DUSP [nucleoplasm] (Mus musculus)

Other forms of this molecule

DUSP7 [cytosol]

Inferred From

DUSP7 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_703189.3

Ensembl

ENSMUSG00000053716, ENSMUSP00000126984, ENSMUST00000172306

PRO

Q91Z46

MGI

2387100

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