Reactome | Plexin-A2 [plasma membrane]

Plexin-A2 [plasma membrane]

Stable Identifier

R-MMU-2045918

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Plxna2, PLXA2_MOUSE, Plxna2

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - Semaphorin interactions (Mus musculus)
      - CRMPs in Sema3A signaling (Mus musculus)
        
        Phosphorylation of CRMPs by Cdk5 (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        Plexin-A1-4 [plasma membrane] (Mus musculus)
        
        Plexin-A2 [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Mus musculus)
        
        PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Mus musculus)
        
        Plexin-A1-4 [plasma membrane] (Mus musculus)
        
        Plexin-A2 [plasma membrane] (Mus musculus)
        
        Phosphorylation of CRMPs by GSK3beta (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        Plexin-A1-4 [plasma membrane] (Mus musculus)
        
        Plexin-A2 [plasma membrane] (Mus musculus)
      - SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Mus musculus)
        
        Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)
        
        NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Mus musculus)
        
        Plexin-A1-4:FYN:FARP2 [plasma membrane] (Mus musculus)
        
        Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Plexin-A1-4 [plasma membrane] (Mus musculus)
        
        Plexin-A2 [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Mus musculus)
        
        NRP1:Plexin-A1-4:FYN [plasma membrane] (Mus musculus)
        
        Plexin-A1-4 [plasma membrane] (Mus musculus)
        
        Plexin-A2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P70207 Plxna2

Gene Names

Plxna2, Kiaa0463

Chain

signal peptide:1-34, chain:35-1894

Reference Genes

BioGPS Gene:18845 Plxna2

ENSEMBL:ENSMUSG00000026640.13 Plxna2

KEGG Gene (Mus musculus):18845 Plxna2

Monarch:18845 Plxna2

NCBI Gene:18845 Plxna2

UCSC:P70207 Plxna2

Reference Transcript

RefSeq:NM_008882.2 Plxna2

Other Identifiers

10352867

106447_at

114755_at

1429772_at

1451753_at

1453286_at

1455037_at

167172_i_at

17220974

18845

4392188

4487605

4532493

4545381

4552655

4570341

4583293

4596361

4628626

4716195

4779089

4798735

4806161

4881356

4968409

4970592

5006790

5007431

5018604

5031531

5094669

5098254

5101947

5133960

5143744

5145553

5217964

5238635

5257742

5282239

5329143

5338936

5359727

5361567

5368163

5372344

5378731

5393653

5421833

5425288

5425886

5476177

5492704

5492877

5560087

5616044

95368_at

A_51_P110529

A_51_P229602

A_52_P431981

D86949_s_at

GE33138

GO:0001756

GO:0002116

GO:0005515

GO:0005886

GO:0007155

GO:0007162

GO:0007166

GO:0008360

GO:0016020

GO:0017154

GO:0021915

GO:0021935

GO:0023052

GO:0030154

GO:0030312

GO:0030334

GO:0031012

GO:0042802

GO:0048856

GO:0048870

GO:0050772

GO:0051642

GO:0060037

GO:0060089

GO:0060174

GO:0062023

GO:0071526

GO:1902287

ILMN_2482866

ILMN_2701815

mMC003929

mMR027094

Participates

as a member of

Other forms of this molecule

phospho-Plxna2 [plasma membrane]

Inferred From

PLXNA2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_032908.2

Ensembl

ENSMUSG00000026640, ENSMUST00000027952, ENSMUSP00000027952

PRO

P70207

MGI

107684

PDB

5L74, 5L5G, 3OKT, 3AL9, 3OKY, 4GZA, 3AL8

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P97333 Nrp1	1	Nrp1 [plasma membrane] (R-MMU-421085)	0.558	3