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Nck2 [cytosol]
Stable Identifier
R-MMU-204885
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
NCK2, O55033
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Mus musculus)
Nephrin family interactions (Mus musculus)
Nephrin binds NCK (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
Ephrin signaling (Mus musculus)
EFNB:GRB4 binds GIT1 (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
GIT1 binds bPIX (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
PAK binds RAC and bPIX (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
PAKs autophosphorylate (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
p-EFNB binds GRB4 (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
Nck binds to the active PDGF receptor (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
CDC42:GTP binds PAK2 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
FYN autophosphorylates (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
FYN phosphorylates PAK2 (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
PAK2 autophorylates (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
PAK2 binds NCK (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
p-6Y-VEGFR2 binds FYN (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
p-6Y-VEGFR2 binds NCK (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
p-Y420-FYN is phosphorylated on S21 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
p38 MAPK activation by VEGFR (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RHOU GTPase cycle (Mus musculus)
RHOU binds effectors at the plasma membrane (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
RHOU:GTP:RHOU effectors [plasma membrane] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
RHOV GTPase cycle (Mus musculus)
RHOV binds effectors at the plasma membrane (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
RHOV:GTP:RHOV effectors [plasma membrane] (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
Nck2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O55033 Nck2
Gene Names
Nck2, Grb4
Chain
initiator methionine:, chain:2-380
Reference Genes
BioGPS Gene:17974 Nck2
ENSEMBL:ENSMUSG00000066877 Nck2
KEGG Gene (Mus musculus):17974 Nck2
Monarch:17974 Nck2
NCBI Gene:17974 Nck2
UCSC:O55033 Nck2
Reference Transcript
RefSeq:NM_010879.3 Nck2
Other Identifiers
10345913
1416796_at
1416797_at
17212355
17974
4479438
4489616
5046241
5181615
5346156
5452617
5559991
5591644
93948_at
A_52_P372925
A_55_P2117741
GE36425
GO:0001771
GO:0001784
GO:0002376
GO:0005515
GO:0005737
GO:0005783
GO:0005829
GO:0006351
GO:0006355
GO:0006417
GO:0007010
GO:0007015
GO:0007155
GO:0012501
GO:0012506
GO:0014069
GO:0016477
GO:0023052
GO:0030032
GO:0030154
GO:0030838
GO:0033137
GO:0036211
GO:0036493
GO:0042102
GO:0043226
GO:0044877
GO:0045202
GO:0045944
GO:0048013
GO:0048856
GO:0048870
GO:0060996
GO:0065003
GO:0097110
GO:1902237
GO:1903898
GO:1903912
GO:1990441
ILMN_2596917
mMC026046
Participates
as a candidate of
RHOV effectors [cytosol] (Mus musculus)
as a member of
RHOU effectors [cytosol] (Mus musculus)
NCK1,NCK2 [cytosol] (Mus musculus)
as an input of
p-EFNB binds GRB4 (Mus musculus)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Mus musculus)
Other forms of this molecule
Nck2 [cytosol]
Inferred From
NCK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035009.3
Ensembl
ENSMUSG00000066877
,
ENSMUST00000086421
,
ENSMUSP00000083611
PRO
O55033
MGI
1306821
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O70469
1
Dok2 [cytosol]
(R-MMU-204823)
0.564
2
UniProt:P52800 Efnb2
3
phospho-Efnb2 [plasma membrane]
(R-MMU-3928387)
Ephrin-B2 [plasma membrane]
(R-MMU-3928450)
Efnb2 [plasma membrane]
(R-MMU-2682330)
0.462
2
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