NGF:p75NTR complex binds to Nrage

Stable Identifier
R-MMU-204967
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NGF:p75NTR complex binds to Nrage
NRAGE (neurotrophin receptor-interacting MAGE homolog), a member of the MAGE family of proteins, is a cytoplasmic protein that mediates neurotrophin-induced cell death. NRAGE binding is stimulated following NGF (or proNGF) binding to p75NTR. Some studies indicate that NRAGE expression is limited to proliferative neural populations, whereas others indicate its presence in differentiated neurons in hippocampus. Another MAGE protein, Necdin, was reported to interact with p75NTR and affect cell death.
Literature References
PubMed ID Title Journal Year
10985348 NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis

Bhakar, A, Tannis, LL, Salehi, AH, Kubu, CJ, Roux, PP, Barker, PA, Verdi, JM, Zeindler, C

Neuron 2000
Participants
Input
Output
Orthologous Events
NGF:p75NTR complex binds to NRAGE (Homo sapiens)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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