Notch1 binds Jag1

Stable Identifier
R-MMU-2053963
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Notch1 binds Jag1
Cultured mouse endothelial cells expressing Notch1 are activated by immobilized mouse Jag1, as demonstrated by expression of Notch target genes Hes1 and Hey1. The activation of Notch1 by Jag1 is confirmed by a co-culture assay in which Jag1-expressing cells are mixed with Notch1-expressing cells transfected with the Notch reporter construct.
Literature References
PubMed ID Title Journal Year
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Adams, S, Gossler, A, Adams, RH, Fruttiger, M, Roca, C, Sörensen, I

Cell 2009
Participants
Orthologous Events
Authored
Reviewed
Created
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