Notch1 binds Jag1

Stable Identifier
R-MMU-2053963
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Notch1 binds Jag1
Cultured mouse endothelial cells expressing Notch1 are activated by immobilized mouse Jag1, as demonstrated by expression of Notch target genes Hes1 and Hey1. The activation of Notch1 by Jag1 is confirmed by a co-culture assay in which Jag1-expressing cells are mixed with Notch1-expressing cells transfected with the Notch reporter construct.
Literature References
PubMed ID Title Journal Year
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Adams, S, Gossler, A, Adams, RH, Fruttiger, M, Roca, C, Sörensen, I

Cell 2009
Participants
Input
Output
Entity On Other Cell
Orthologous Events
NOTCH1 binds JAG1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-12)
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