Reactome | Ywhaz [cytosol]

Ywhaz [cytosol]

Stable Identifier

R-MMU-206099

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

YWHAZ, P63101

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Mus musculus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)

Programmed Cell Death (Mus musculus)

- Apoptosis (Mus musculus)
  - Intrinsic Pathway for Apoptosis (Mus musculus)
    - Activation of BH3-only proteins (Mus musculus)
      - Activation of BAD and translocation to mitochondria (Mus musculus)
        
        Activation of BAD by calcineurin (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        Sequestration of BAD protein by 14-3-3 (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by NOTCH (Mus musculus)
  - Signaling by NOTCH4 (Mus musculus)
    - NOTCH4 Activation and Transmission of Signal to the Nucleus (Mus musculus)
      - NICD4 traffics to the nucleus (Mus musculus)
        
        p-4S-NICD4:YWHAZ dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases activate PKNs (Mus musculus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
- Signaling by WNT (Mus musculus)
  - TCF dependent signaling in response to WNT (Mus musculus)
    - Deactivation of the beta-catenin transactivating complex (Mus musculus)
      - YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)
        
        XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P63101 Ywhaz

Gene Names

Ywhaz

Chain

chain:1-245

Reference Genes

BioGPS Gene:22631 Ywhaz

KEGG:mmu:22631 Ywhaz

Monarch:22631 Ywhaz

NCBI Gene:22631 Ywhaz

UCSC:P63101 Ywhaz

Reference Transcript

Other Identifiers

10428204

10493891

1416102_at

1416103_at

1436971_x_at

1448218_s_at

1448219_a_at

17316545

17399904

22631

4318872

4390237

4406267

4492368

4496281

4644992

4671887

4737754

4744184

4832503

4849367

5026454

5034564

5144777

5175395

5219991

5220935

5224545

5249467

5252476

5313247

5341467

5341673

5383375

5420151

5427389

5432839

5473754

5568047

5593786

97544_at

A_52_P225260

A_55_P1987245

A_55_P2902921

A_66_P120770

GE36295

GO:0000122

GO:0001525

GO:0002553

GO:0003016

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0006355

GO:0006468

GO:0006605

GO:0006626

GO:0007165

GO:0008039

GO:0008104

GO:0009410

GO:0019901

GO:0019904

GO:0030324

GO:0031252

GO:0031410

GO:0031625

GO:0032991

GO:0035148

GO:0042149

GO:0042470

GO:0042802

GO:0043067

GO:0043226

GO:0044325

GO:0044877

GO:0045184

GO:0045824

GO:0048471

GO:0048856

GO:0050815

GO:0051683

GO:0070371

GO:0070372

GO:0090128

GO:0090168

GO:0098686

GO:0098978

GO:0099572

GO:0140297

GO:0140311

GO:0140313

GO:1900181

GO:1904262

ILMN_2510612

ILMN_2952914

Msa.11098.0_i_at

d78647_s_at

mMC020595

Participates

as a member of

14-3-3 beta, zeta [cytosol] (Mus musculus)

as an input of

p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)

as a component of

Other forms of this molecule

14-3-3zeta [cytosol]

Ywhaz [nucleoplasm]

Inferred From

YWHAZ [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001240734.1, XP_011243654.1, NP_035870.1, NP_001240735.1

ENSEMBL

ENSMUST00000022894, ENSMUST00000110361, ENSMUST00000110362, ENSMUSP00000022894, ENSMUSP00000105990, ENSMUSP00000105991

PRO

P63101

GlyGen

P63101

MGI

109484

PDB

7EXE

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S006	1	LRRK2 [cytosol] (R-MMU-5661173)	0.677	5
UniProt:Q4ACU6	1	Shank3 [cytosol] (R-MMU-6794277)	0.643	3
IntAct:EBI-1179609 H3			0.639	17
UniProt:Q9QWV4 MLF1			0.632	3
UniProt:Q92945 KHSRP	4	p-S193-KHSRP [nucleoplasm] (R-HSA-450452) p-T692-KHSRP [cytosol] (R-HSA-451177) p-S193-KHSRP [cytosol] (R-HSA-450505) KSRP [cytosol] (R-HSA-450485)	0.592	2
UniProt:Q61097	5	phospho-p-S311,S406 KSR1 [cytosol] (R-MMU-5672654) KSR1 [cytosol] (R-MMU-5672587) phospho-p-S311 KSR1 [cytosol] (R-MMU-5672652) phospho-p-S311,Y602 KSR1 [plasma membrane] (R-MMU-5672659) phospho-p-S311,Y602 KSR1 [cytosol] (R-MMU-5672656)	0.547	2
UniProt:O35929 REM1			0.544	2
UniProt:F6SEU4	1	Syngap1 [cytosol] (R-MMU-5658217)	0.527	2

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