Gamma secretase cleaves Dner:Notch1 complex

Stable Identifier
R-MMU-2067638
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gamma secretase cleaves Dner:Notch1 complex
In the mouse myogenic cell line C2C12, transfected with a full-length mouse Notch1 expressing vector, NICD1 produced by S3 cleavage is detectable after cells are treated with a soluble recombinant mouse Dner. Also, the effect of soluble Dner on morphology of Notch1 expressing primary glial cells isolated from mouse cerebellum is dependent on the activity of gamma-secretase.
Literature References
PubMed ID Title Journal Year
15965470 DNER acts as a neuron-specific Notch ligand during Bergmann glial development

Kengaku, M, Eiraku, M, Ono, K, Kaneko, M, Fujishima, K, Tohgo, A, Hirano, T

Nat Neurosci 2005
Participants
Input
Output
Entity On Other Cell
This event is regulated
Positively by
Regulator
gamma-secretase [plasma membrane] (Mus musculus)
Orthologous Events
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-25)
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