Numb recruits Itch to Notch1

Stable Identifier
R-MMU-2077477
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Numb recruits Itch to Notch1
By expressing exogenous recombinant mouse Notch1, Numb and Itch in human embryonic kidney cell line HEK293 and mouse myogenic cell line C2C12, it was shown that Numb over-expression results in a reduction of the internalized pool of biotinylated Notch1.This effect depends on the presence of an Itch-interacting domain of Numb.
Literature References
PubMed ID Title Journal Year
19567869 Numb regulates post-endocytic trafficking and degradation of Notch1

McGill, MA, McGlade, CJ, Weinmaster, G, Dho, SE

J Biol Chem 2009
Participants
Input
Output
Orthologous Events
NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-28)
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