Murine MKK4 kinase is phosphorylated and activated by Phospho TAK1:Phospho TAB1:Phospho TAB2 kinase complex

Stable Identifier
R-MMU-209329
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
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Murine MKK4 kinase is phosphorylated and activated by Phospho TAK1:Phospho TAB1:Phospho TAB2 kinase complex
In Mouse, MKK4 kinase is phosphorylated in its activation loop at Ser255 and Thr259 by phosphorylated TAK1 kinase.
Literature References
PubMed ID Title Journal Year
15218018 Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells

Kobayashi, T, Kanamaru, R, Yonezawa, T, Ninomiya-Tsuji, J, Kudo, TA, Li, MG, Akiyama, S, Matsumoto, K, Ito, M, Wang, H, Yoshioka, K, Tamura, S

J Biol Chem 2004
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Phospho TAK1 [cytosol]

Physical Entity
Phospho TAK1 [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex (Drosophila melanogaster)
Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2007-07-12)
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