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PAK2 [cytosol]
Stable Identifier
R-MMU-211604
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q8CIN4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
Ephrin signaling (Mus musculus)
PAK binds RAC and bPIX (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAKs autophosphorylate (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1/3, 2 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Semaphorin interactions (Mus musculus)
Sema3A PAK dependent Axon repulsion (Mus musculus)
Activation of PAK by Rac1 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Regulation of T cell activation by CD28 family (Mus musculus)
Co-stimulation by CD28 (Mus musculus)
CD28 dependent Vav1 pathway (Mus musculus)
Activation of PAKs by RAC1 and CDC42 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Generation of second messenger molecules (Mus musculus)
NCK binds PAK (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
p-SLP-76:NCK:PAK [cytosol] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CD209 (DC-SIGN) signaling (Mus musculus)
PAK phosphorylates p21 RAF1 on S338 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
PAK dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
Activation of PAKs by RAC1 and CDC42 (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
CDC42:GTP binds PAK2 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
PAK2 dimer:CDC42:GTP [plasma membrane] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK2 autophorylates (Mus musculus)
PAK2 [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
PAK2 dimer:CDC42:GTP [plasma membrane] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK2 binds NCK (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
PAK1-3 autophosphorylates (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1-3 dimer disassociates (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RAC1 binds PAK1-3 (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK1,2,3 dimer [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases activate PAKs (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RAC1 and CDC42 activate PAK2 (Mus musculus)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 binds effectors at the plasma membrane (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Mus musculus)
RAC1 effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RAC2 GTPase cycle (Mus musculus)
RAC2 binds effectors at the plasma membrane (Mus musculus)
RAC2 plasma membrane effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Mus musculus)
RAC2 plasma membrane effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RAC3 GTPase cycle (Mus musculus)
RAC3 binds effectors at the plasma membrane (Mus musculus)
RAC3 effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RAC3:GTP:RAC3 effectors [plasma membrane] (Mus musculus)
RAC3 effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOG GTPase cycle (Mus musculus)
RHOG binds effectors at the plasma membrane (Mus musculus)
RHOG plasma membrane effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Mus musculus)
RHOG plasma membrane effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOH GTPase cycle (Mus musculus)
RHOH binds effectors at the plasma membrane (Mus musculus)
RHOH effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOH:GTP:RHOH effectors [plasma membrane] (Mus musculus)
RHOH effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOQ GTPase cycle (Mus musculus)
RHOQ binds effectors at the plasma membrane (Mus musculus)
RHOQ effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Mus musculus)
RHOQ effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOU GTPase cycle (Mus musculus)
RHOU binds effectors at the plasma membrane (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOU:GTP:RHOU effectors [plasma membrane] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOV GTPase cycle (Mus musculus)
RHOV binds effectors at the plasma membrane (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
RHOV:GTP:RHOV effectors [plasma membrane] (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
PAK2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8CIN4
Reference Genes
BioGPS Gene:224105
ENSEMBL:ENSMUSG00000022781
KEGG:mmu:224105
Monarch:224105
NCBI Gene:224105
UCSC:Q8CIN4
Reference Transcript
RefSeq:XM_006522072.3
RefSeq:NM_177326.3
Other Identifiers
10439032
129281_at
1434250_at
1454887_at
163606_at
17329790
224105
4353189
4357501
4532658
4551002
4588866
4599152
4628578
4766690
4771597
4837082
4857353
4859543
4882819
4918877
4953095
5006587
5037969
5214577
5284039
5307183
5407249
5448950
5536973
5592523
97821_at
97822_at
97823_g_at
A_51_P172323
A_52_P12919
A_52_P332125
A_55_P2713700
GE1528210
GO:0003012
GO:0003300
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005911
GO:0006468
GO:0006915
GO:0012501
GO:0014069
GO:0016020
GO:0016740
GO:0019901
GO:0030141
GO:0030296
GO:0031267
GO:0031410
GO:0034330
GO:0034333
GO:0035556
GO:0042802
GO:0043066
GO:0043226
GO:0043408
GO:0048471
GO:0048856
GO:0050731
GO:0050770
GO:0051493
GO:0051497
GO:0060996
GO:0070830
GO:0071407
GO:0071560
GO:0098772
GO:0098978
GO:0106310
GO:0140096
GO:0150105
GO:2001238
ILMN_1215465
ILMN_1259543
ILMN_2645390
Msa.11606.0_s_at
Msa.4973.0_s_at
mMC019711
mMC024027
mMR027409
Participates
as a candidate of
PAK1/3, 2 [cytosol] (Mus musculus)
as an output of
RAC1 and CDC42 activate PAK2 (Mus musculus)
as a component of
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Mus musculus)
PAK2 dimer [cytosol] (Mus musculus)
as a member of
PAK1,2,3 [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-S141,T402-PAK2 [plasma membrane]
phospho-p-Y130,S141,T402-PAK2 [cytosol]
phospho-p-S141,T402-PAK2 [cytosol]
Inferred From
PAK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006522135.1
,
NP_796300.1
ENSEMBL
ENSMUST00000023467
,
ENSMUSP00000023467
PRO
Q8CIN4
MGI
1339984
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