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Smad7 [cytosol]
Stable Identifier
R-MMU-2161209
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Mothers against decapentaplegic homolog 7, MAD homolog 7
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Mus musculus)
SMAD7:SMURF2 [cytosol] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by BMP (Mus musculus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Mus musculus)
I-SMAD:SMURF [cytosol] (Mus musculus)
I-SMAD [cytosol] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
I-SMAD:SMURF [cytosol] (Mus musculus)
I-SMAD [cytosol] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Mus musculus)
I-SMAD [cytosol] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
I-SMAD:p-2S-SMAD1/5/8 [cytosol] (Mus musculus)
I-SMAD [cytosol] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
I-Smad competes with R-Smad1/5/8 for type I receptor (Mus musculus)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Mus musculus)
I-SMAD [cytosol] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
I-SMAD [cytosol] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)
Smad7 [cytosol] (Mus musculus)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
Degradation of TGF-beta receptor complex (Mus musculus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Mus musculus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)
Smad7 [cytosol] (Mus musculus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)
Smad7 [cytosol] (Mus musculus)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Mus musculus)
Smad7 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O35253 Smad7
Gene Names
Smad7, Madh7, Madh8
Chain
chain:1-426
Reference Genes
BioGPS Gene:17131 Smad7
ENSEMBL:ENSMUSG00000025880.12 Smad7
KEGG Gene (Mus musculus):17131 Smad7
Monarch:17131 Smad7
NCBI Gene:17131 Smad7
UCSC:O35253 Smad7
Reference Transcript
RefSeq:XM_006525703.2 Smad7
RefSeq:NM_001042660.1 Smad7
Other Identifiers
10456745
1423389_at
1443771_x_at
17131
17351862
4353758
4382919
4662798
4755660
4862918
5022382
5026404
5056259
5170000
5270479
5323036
5351942
5404225
5587094
92216_at
A_51_P403636
A_55_P2741400
GE33980
GO:0000122
GO:0001650
GO:0001657
GO:0002376
GO:0002725
GO:0003012
GO:0003013
GO:0003714
GO:0005515
GO:0005518
GO:0005634
GO:0005654
GO:0005667
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0006351
GO:0006355
GO:0006357
GO:0007155
GO:0007179
GO:0008013
GO:0009653
GO:0010717
GO:0010801
GO:0010944
GO:0017015
GO:0022409
GO:0023052
GO:0030154
GO:0030279
GO:0030512
GO:0030514
GO:0031397
GO:0031503
GO:0031625
GO:0032926
GO:0032991
GO:0033137
GO:0034330
GO:0034333
GO:0034616
GO:0034713
GO:0035556
GO:0036211
GO:0043226
GO:0046872
GO:0048844
GO:0048856
GO:0050821
GO:0055010
GO:0055117
GO:0060090
GO:0060373
GO:0060392
GO:0060395
GO:0060412
GO:0070411
GO:0070697
GO:0071144
GO:0071560
GO:0098772
GO:0140110
GO:0140416
GO:1902731
GO:1903043
GO:1990756
GO:1990830
GO:2000317
GO:2000320
ILMN_2759660
mMC009969
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-Smad7 [plasma membrane] (Homo sapiens)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Mus musculus)
Smad7:SMURF1 [cytosol] (Homo sapiens)
Smad7:SMURF2 [cytosol] (Homo sapiens)
SMAD7:SMURF2 [cytosol] (Mus musculus)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Mus musculus)
Smad7:NEDD4L [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:Smad7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Mus musculus)
as a member of
I-SMAD [cytosol] (Mus musculus)
as an input of
BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)
as an output of
PP1CC dephosphorylates TGFBR1 (Homo sapiens)
Other forms of this molecule
Smad7 [nucleoplasm]
Inferred From
SMAD7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006525766.1
,
NP_001036125.1
Ensembl
ENSMUST00000026999
,
ENSMUSP00000026999
,
ENSMUSG00000025880
PRO
O35253
MGI
1100518
PDB
7CD1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-5211238)
SIRT1 [nucleoplasm]
(R-MMU-427531)
0.524
6
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