PGH2 is reduced to PGF2a by Fam213b

Stable Identifier
R-MMU-2161718
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PGH2 is reduced to PGF2a by Fam213b

In mice, prostamide/prostaglandin F synthase, Fam213b and thioredoxin (Txn) are the proteins involved in the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Moriuchi et al. 2008, Yoshikawa et al. 2011).

Literature References
PubMed ID Title Journal Year
18006499 Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily

Daiyasu, H, Moriuchi, H, Ogasawara, K, Woodward, DF, Okuda-Ashitaka, E, Watanabe, K, Ito, S, Koda, N, Toh, H

J Biol Chem 2008
20950588 Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

Takei, S, Kawamura, N, Hosokawa, M, Shimada, A, Woodward, DF, Hasegawa-Ishii, S, Furukawa, A, Watanabe, K, Yoshikawa, K, Chiba, Y

Brain Res 2011
Participants
Input
Output
Catalyst Activity

thioredoxin peroxidase activity of Fam213b [cytosol]

Physical Entity
Fam213b [cytosol] (Mus musculus)
Activity
thioredoxin peroxidase activity (GO:0008379)
Orthologous Events
PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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