Insulin secretory granule translocates to cell cortex

Stable Identifier
R-MMU-216852
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
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PNG
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Insulin secretory granule translocates to cell cortex
Insulin-containing secretory vesicles are translocated along microtubules (polymerized tubulin) from the trans-golgi to the cellular cortex. Motor activity is provided by Kinesin-1 but the complex that connects the secretory granule to the Kinesin-1 is not yet fully known. The process is stimulated by intracellular calcium ions (Ca2+).
Literature References
PubMed ID Title Journal Year
14592410 Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells

Rutter, GA, Allan, VJ, Varadi, A, Johnson-Cadwell, LI, Tsuboi, T

Biochem Biophys Res Commun 2003
9112396 Suppression of the expression of a pancreatic beta-cell form of the kinesin heavy chain by antisense oligonucleotides inhibits insulin secretion from primary cultures of mouse beta-cells

Meng, YX, Balczon, R, Varden, CH, Wilson, GW, Avery, MC

Endocrinology 1997
16714477 Insulin vesicle release: walk, kiss, pause ... then run

Rutter, GA, Hill, EV

Physiology (Bethesda) 2006
Participants
Input
Output
Catalyst Activity

microtubule motor activity of Kinesin-1 [cytosol]

Physical Entity
Kinesin-1 [cytosol] (Mus musculus)
Activity
microtubule motor activity (GO:0003777)
Orthologous Events
Insulin secretory granule translocates to cell cortex (Homo sapiens)
Authored
May, B  (2008-11-20)
Gopinathrao, G  (2008-11-20)
Reviewed
May, B  (2009-10-29)
Created
May, B  (2008-03-23)
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