Active Mmp3 can cleave pro-Hbegf to form active Hbegf

Stable Identifier
R-MMU-2203911
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Active Mmp3 can cleave pro-Hbegf to form active Hbegf

Gastrin can induce cleavage of pro-Hbegf via stromelysin-1 (Mmp3), releasing mature Hbegf (Suzuki et al. 1997).

Literature References
PubMed ID Title Journal Year
9395517 Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site

Suzuki, M, Raab, G, Moses, MA, Fernandez, CA, Klagsbrun, M

J Biol Chem 1997
Participants
Catalyst Activity

metalloendopeptidase activity of Mmp3 [extracellular region]

Orthologous Events
Authored
Reviewed
Created
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