Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by Pstk

Stable Identifier
R-MMU-2408505
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by Pstk
In mice, L-seryl-tRNA(Sec) kinase (Pstk) phosphorylates the serylated transfer RNA (tRNA) for Sec (Ser-tRNASec) to form Sep-tRNASec in the presence of ATP and Mg2+ (Carlson et al. 2004). PSTK exhibits a strict selectivity for Ser-tRNASec. It does not phosphorylate free Ser or Ser attached to its cognate tRNASer.
Literature References
PubMed ID Title Journal Year
15317934 Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase

Carlson, BA, Xu, XM, Kryukov, GV, Rao, M, Berry, MJ, Gladyshev, VN, Hatfield, DL

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Input
Output
Catalyst Activity

seryl-selenocysteinyl-tRNA kinase activity of Pstk:Mg2+ [cytosol]

Physical Entity
Pstk:Mg2+ [cytosol] (Mus musculus)
Activity
seryl-selenocysteinyl-tRNA kinase activity (GO:0098620)
Orthologous Events
Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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