Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by Pstk

Stable Identifier
R-MMU-2408505
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by Pstk

In mice, L-seryl-tRNA(Sec) kinase (Pstk) phosphorylates the serylated transfer RNA (tRNA) for Sec (Ser-tRNASec) to form Sep-tRNASec in the presence of ATP and Mg2+ (Carlson et al. 2004). PSTK exhibits a strict selectivity for Ser-tRNASec. It does not phosphorylate free Ser or Ser attached to its cognate tRNASer.

Literature References
PubMed ID Title Journal Year
15317934 Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase

Carlson, BA, Kryukov, GV, Berry, MJ, Hatfield, DL, Rao, M, Gladyshev, VN, Xu, XM

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Catalyst Activity

seryl-selenocysteinyl-tRNA kinase activity of Pstk:Mg2+ [cytosol]

Orthologous Events
Authored
Reviewed
Created
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