Laminins bind Nidogens 1, 2

Stable Identifier
R-MMU-2426496
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Laminins bind Nidogens 1, 2
Nidogen-1 and nidogen-2, also known as the entactins, are basement membrane glycoproteins with three globular domains (G1, G2, G3) separated by rod-like regions. They form stable complexes with laminins and collagen IV (Fox et al. 1991, Salmivirta et al. 2002), thereby acting as the major linking agent in basement membrane ECM (Nischt et al. 2007). Nidogen-1 binds to the laminin-1 gamma subunit (Mayer et al. 1998). Although the gamma-2 chain of laminin-332 contains a homologous binding module, nidogen-1 does not appear to bind this laminin (Mayer et al. 1995). Laminin gamma-3 has been shown to bind to nidogen-1 and -2 with a lower affinity than with gamma-1 (Gersdorff et al. 2005).
Literature References
PubMed ID Title Journal Year
1717261 Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen type IV

Engel, J, Mann, K, Fox, JW, Timpl, R, Krieg, T, Mayer, U, Nischt, R, Wiedemann, H, Reinhardt, D, Aumailley, M

EMBO J. 1991
15824114 Laminin gamma3 chain binds to nidogen and is located in murine basement membranes

Kohfeldt, E, Gersdorff, N, Sasaki, T, Miosge, N, Timpl, R

J. Biol. Chem. 2005
12243745 Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens

Ekblom, P, Olsson, M, Salmivirta, K, Talts, JF, Sasaki, T, Timpl, R

Exp. Cell Res. 2002
Participants
Input
Output
Orthologous Events
Laminins bind Nidogens 1, 2 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-08-03)
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