Reactome | Degradation of laminin-111, -332 by Mmp3, 7, 12, 13, 19, 20 and plasmin

Degradation of laminin-111, -332 by Mmp3, 7, 12, 13, 19, 20 and plasmin

Stable Identifier

R-MMU-2533953

Type

Reaction [transition]

Species

Mus musculus

Compartment

extracellular region

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Degradation of laminin-111, -332 by Mmp3, 7, 12, 13, 19, 20 and plasmin

Laminins are degraded by MMP3 (Okada et al. 1986, Bejanaro et al. 1988), MMP7 (Miyazaki et al. 1990), MMP12 (Chandler et al. 1996), MMP13, MMP20 (Pirilä et al. 2003), MMP14 (Ohuchi et al. 1997), MMP19 (Sadowski et al. 2005) and plasmin (Chen & Strickland 1993, Gutiérrez-Fernández et al. 2009). In most of this literature it is not clear which subunit of the laminin trimer has been cleaved; MMPs are reportedly capable of cleaving all three subunits of laminin-332, namely laminin beta-3 (Udayakumar et al. 2003), alpha-5 (Bair et al. 2005) and gamma-2 (Gianelli et al. 1997, Pirilä et al. 2003, Koshikawa et al. 2005). Plasmin cleavage of laminin-111 yields fragments with sizes that correspond to the alpha and beta/gamma components (Gutiérrez-Fernández et al. 2009). In this reaction laminin is represented with all 3 component peptides cleaved.

Literature References

PubMed ID	Title	Journal	Year
9428515	Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin Chen, ZL, Strickland, S	Cell	1997
3223920	Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin) Bejarano, PA, Hudson, BG, Noelken, ME, Nagase, H, Suzuki, K	Biochem J	1988
3095317	A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization Okada, Y, Harris ED, Jr, Nagase, H	J Biol Chem	1986
8920930	Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein Wells, G, Lury, J, Chandler, S, Cossins, J	Biochem Biophys Res Commun	1996
19812315	Plasminogen enhances neuritogenesis on laminin-1 Gingles, NA, Parmer, RJ, Bai, H, Miles, LA, Castellino, FJ, Gutiérrez-Fernández, A	J. Neurosci.	2009
15868410	Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration Sedlacek, R, Sadowski, T, Ludwig, A, Proksch, E, Koschinsky, F, Titz, B, Dietrich, S	Cell. Mol. Life Sci.	2005
12684035	Matrix metalloproteinases process the laminin-5 gamma 2-chain and regulate epithelial cell migration Sorsa, T, Pirilä, E, Quaranta, V, Heljasvaara, R, Sharabi, A, Tu, H, Salo, T, Koshikawa, N, Maisi, P	Biochem. Biophys. Res. Commun.	2003
2253219	Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line Umenishi, F, Yasumitsu, H, Miyazaki, K, Umeda, M, Hattori, Y	Cancer Res	1990