Reactome | Lmna [nucleoplasm]

Lmna [nucleoplasm]

Stable Identifier

R-MMU-264872

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Lamin C, P48678

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Nuclear Envelope (NE) Reassembly (Mus musculus)
        
        Initiation of Nuclear Envelope (NE) Reformation (Mus musculus)
        
        BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin C dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)
    - Mitotic Prophase (Mus musculus)
      - Nuclear Envelope Breakdown (Mus musculus)
        
        Depolymerization of the Nuclear Lamina (Mus musculus)
        
        Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin C dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)
        
        VRK1/VRK2 phosphorylate BANF1 (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin C dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin C dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P48678-1 Lmna

Gene Names

Lmna, Lmn1

Other Identifiers

10499394

1421654_a_at

1425472_a_at

1457670_s_at

16905

17406783

4307703

4445885

4479405

4524756

4584993

4687050

4817758

4828760

4878601

4938777

5039122

5114835

5162232

5214105

5316587

5350783

5387647

5510638

5549630

98059_s_at

98060_at

A_51_P313561

A_51_P313566

A_52_P137765

A_65_P12904

GE37391

GO:0003012

GO:0005198

GO:0005200

GO:0005515

GO:0005634

GO:0005635

GO:0005638

GO:0005652

GO:0005654

GO:0005694

GO:0005856

GO:0005882

GO:0006325

GO:0006606

GO:0006886

GO:0006913

GO:0006997

GO:0006998

GO:0007005

GO:0007010

GO:0007097

GO:0007163

GO:0007517

GO:0008104

GO:0008157

GO:0008285

GO:0010628

GO:0012501

GO:0016363

GO:0016607

GO:0023052

GO:0030010

GO:0030154

GO:0030334

GO:0030951

GO:0031507

GO:0031647

GO:0031965

GO:0032200

GO:0032204

GO:0034399

GO:0034504

GO:0035861

GO:0042802

GO:0043226

GO:0045669

GO:0048471

GO:0048856

GO:0048870

GO:0051664

GO:0055015

GO:0061024

GO:0071456

GO:0072201

GO:0090201

GO:0090398

GO:0090435

GO:1900180

GO:1903243

GO:1904178

GO:1990683

GO:2001237

ILMN_1221646

ILMN_1254405

ILMN_1255510

ILMN_2662387

ILMN_3121891

d49733-3_s_at

mMC016894

mMC023449

Participates

as a component of

Lamin C dimer [nucleoplasm] (Mus musculus)

Other forms of this molecule

p-S22,S392-Lmna-1 [nucleoplasm]

Lmna-1 [nucleoplasm]

phospho-Lmna [nucleoplasm]

Lmna [cytosol]

Lmna [nuclear envelope]

Lmna [nucleoplasm]

Inferred From

Lamin C [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001104572.1, NP_001002011.2, NP_062263.1, XP_006501136.1

Ensembl

ENSMUSP00000040265, ENSMUSG00000028063, ENSMUSP00000029699, ENSMUST00000036252, ENSMUSP00000113093, ENSMUST00000120377, ENSMUST00000029699

PRO

P48678

MGI

96794

PDB

1UFG

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31750 Akt1	10	p-T308,S473-Akt1 [plasma membrane] (R-MMU-1445123) p-T308,S473-Akt1 [cytosol] (R-MMU-162346) phospho-p-Y315,Y326-AKT1 [cytosol] (R-MMU-8848757) phospho-p-T308,S473-AKT1 [plasma membrane] (R-MMU-199430) phospho-p-T308-AKT1 [cytosol] (R-MMU-198634) AKT1 [cytosol] (R-MMU-58252) AKT1 [plasma membrane] (R-MMU-199416) phospho-p-S473-AKT1 [plasma membrane] (R-MMU-377265) phospho-p-T308,S473-AKT1 [cytosol] (R-MMU-198356) phospho-p-T308,S473-AKT1 [nucleoplasm] (R-MMU-198357)	0.564	2