Phosphorylated Stat5 Dimer Translocates to the Nucleus

Stable Identifier
R-MMU-2730596
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated Stat5 Dimer Translocates to the Nucleus
Homodimers and heterodimers of phosphoryated Stat5a and Stat5b are translocated from the cytosol into the nucleus (Cella et al. 1998). Stat5 is imported by the importin alpha/beta pathway and import is promoted by Rac1 and MgcRacGAP (Kawashima et al. 2006)
Literature References
PubMed ID Title Journal Year
17178910 Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

Minoshima, Y, Kawashima, T, Hatori, T, Nosaka, T, Nakajima, H, Kiyono, M, Bao, YC, Nomura, Y, Kitamura, T, Williams, DA, Moon, Y, Tsuchiya, A, Tonozuka, Y

J. Cell Biol. 2006
9528750 Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells

Hynes, NE, Cella, N, Groner, B

Mol Cell Biol 1998
11971004 Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner

Watanabe, S, Yoshida, M, Zeng, R, Arai, K, Aoki, Y

J. Immunol. 2002
Participants
Input
Output
Orthologous Events
STAT5 dimers translocate to the nucleus (Homo sapiens)
Authored
May, B  (2012-12-03)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-12-04)
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