Notch2 and phosphorylated Creb1 bind Gzmb promoter

Stable Identifier
R-MMU-2976706
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Notch2 and phosphorylated Creb1 bind Gzmb promoter
In mouse CD8+ T-lymphocytes, Notch2 intracellular domain, NICD2, in complex with Rbpj binds the proximal Rbpj binding element (RBE) of Gzmb (granzyme B) promoter. Creb1, phosphorylated at serine S133, binds a CRE site located 40 bp downstream of the proximal RBE in Gzmb promoter. At the same time, Creb1 associates with NICD2:Rbpj complex and recruits transcriptional coactivator Ep300 (p300). This was demonstrated by chromatin immunoprecipitation (chIP) and gel mobility shift assays (Maekawa et al. 2008).
Literature References
PubMed ID Title Journal Year
18724371 Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity

Saito, T, Sakata-Yanagimoto, M, Kurihara, T, Sone, S, Taniuchi, I, Kojima, H, Minato, Y, Kitamura, A, Ishifune, C, Yasutomo, K, Chiba, S, Yagita, H, Maekawa, Y

Nat. Immunol. 2008
Participants
Input
Output
Orthologous Events
NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Ilagan, MXG  (2013-04-25)
Boyle, S  (2013-04-25)
Created
Orlic-Milacic, M  (2013-01-10)
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