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Nr1h3 [nucleoplasm]
Stable Identifier
R-MMU-3008623
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
NR1H3-1, Q9Z0Y9
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Nuclear Receptor transcription pathway (Mus musculus)
Formation of NR-MED1 Coactivator Complex (Mus musculus)
NR [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR-MED1 Coactivator Complex [nucleoplasm] (Mus musculus)
NR [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
Formation of NR-NCOR Corepressor Complex (Mus musculus)
NR [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR-NCOR CoRepressor Complex [nucleoplasm] (Mus musculus)
NR [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
SUMOylation (Mus musculus)
SUMO E3 ligases SUMOylate target proteins (Mus musculus)
SUMOylation of intracellular receptors (Mus musculus)
HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Mus musculus)
NR1H3:hydroxycholesterol [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
NR1H2 and NR1H3-mediated signaling (Mus musculus)
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis (Mus musculus)
Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene (Mus musculus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Mus musculus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1 [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Mus musculus)
UGT1A3 gene:NR1H2,3:RXR:NCOR [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Mus musculus)
Co-repressor complex dissociates from the transcription unit of the ABCA1 gene (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Mus musculus)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Mus musculus)
NR1H2,3:RXR [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
Transport of small molecules (Mus musculus)
Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
Plasma lipoprotein clearance (Mus musculus)
VLDLR internalisation and degradation (Mus musculus)
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Mus musculus)
NR1H2,NR1H3 [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9Z0Y9
Gene Names
Nr1h3
Reference Genes
BioGPS Gene:22259 Nr1h3
ENSEMBL:ENSMUSG00000002108
ENSEMBL:ENSMUSG00000002108.11 Nr1h3
KEGG Gene (Mus musculus):22259 Nr1h3
Monarch:22259 Nr1h3
NCBI Gene:22259 Nr1h3
UCSC:Q9Z0Y9 Nr1h3
Reference Transcript
RefSeq:XM_006499166.2 Nr1h3
RefSeq:XM_006499168.3 Nr1h3
RefSeq:NM_013839.4 Nr1h3
RefSeq:XM_006499167.2 Nr1h3
RefSeq:NM_001177730.1 Nr1h3
Other Identifiers
104381_at
10484987
1450444_a_at
17388177
22259
4374638
4405386
4428922
4580626
4713255
4720049
4912445
4983913
4989601
5069389
5109433
5181178
5234727
5275783
5350474
5422903
5481192
A_52_P546421
A_55_P2128597
A_66_P120249
GE42722
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006629
GO:0006633
GO:0006954
GO:0008270
GO:0009755
GO:0010867
GO:0010875
GO:0010887
GO:0016071
GO:0016192
GO:0019217
GO:0022600
GO:0023052
GO:0030154
GO:0030522
GO:0031490
GO:0032369
GO:0032376
GO:0032570
GO:0032810
GO:0034145
GO:0036151
GO:0042632
GO:0042789
GO:0043031
GO:0043226
GO:0043235
GO:0043277
GO:0043565
GO:0044255
GO:0044877
GO:0045723
GO:0045861
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0046889
GO:0046965
GO:0048550
GO:0050728
GO:0051247
GO:0055088
GO:0055092
GO:0060089
GO:0070328
GO:0071222
GO:0090188
GO:0090341
GO:0090575
GO:0098542
GO:0120163
GO:0140110
GO:1903573
ILMN_2663374
ILMN_2668472
Msa.24322.0_s_at
mMC019997
Participates
as a component of
NR1H3:hydroxycholesterol [nucleoplasm] (Mus musculus)
NR1H3:RXRB [nucleoplasm] (Mus musculus)
NR1H3:RXRA [nucleoplasm] (Mus musculus)
as a member of
NR1H2,NR1H3 [nucleoplasm] (Mus musculus)
NR [nucleoplasm] (Mus musculus)
Other forms of this molecule
Nr1h3 [nucleoplasm]
Inferred From
NR1H3 [nucleoplasm]
(Homo sapiens)
NR1H3-1 [nucleoplasm]
(Homo sapiens)
NR1H3-2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006499230.1
,
XP_006499231.1
,
NP_001171201.1
,
XP_006499229.1
,
NP_038867.2
Ensembl
ENSMUST00000002177
,
ENSMUST00000111354
,
ENSMUSP00000106986
,
ENSMUSP00000106988
,
ENSMUST00000111356
,
ENSMUSG00000002108
,
ENSMUSP00000002177
PRO
Q9Z0Y9
MGI
1352462
PDB
3FC6
,
3FAL
,
2ACL
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.499
2
UniProt:O88559
4
Men1 [cytosol]
(R-MMU-5672315)
phospho-Men1 [endoplasmic reticulum lumen]
(R-MMU-8956901)
Men1 [endoplasmic reticulum lumen]
(R-MMU-8956785)
Men1 [nucleoplasm]
(R-MMU-2186626)
0.499
3
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