Reactome | Mdm4 [nucleoplasm]

Mdm4 [nucleoplasm]

Stable Identifier

R-MMU-349430

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

MDM4, O35618

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Dependent G1/S DNA damage checkpoint (Mus musculus)
      - p53-Dependent G1 DNA Damage Response (Mus musculus)
        
        Stabilization of p53 (Mus musculus)
        
        MDM2 binds TP53 (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        MDM2 forms homo- or heterodimers (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2,MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        MDM2 ubiquitinates TP53 (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        Phosphorylation of MDM4 by ATM (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - Oncogene Induced Senescence (Mus musculus)
      - MDM2 ubiquitinates TP53 (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
    - Oxidative Stress Induced Senescence (Mus musculus)
      - MDM2 ubiquitinates TP53 (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Methylation (Mus musculus)
        
        MDM2 ubiquitinates JMY (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        Regulation of TP53 Activity through Phosphorylation (Mus musculus)
        
        MDM2 ubiquitinates DYRK2 (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        Regulation of TP53 Expression and Degradation (Mus musculus)
        
        Regulation of TP53 Degradation (Mus musculus)
        
        MDM2 binds TP53 (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        MDM2 forms homo- or heterodimers (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2,MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        MDM2 ubiquitinates TP53 (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)
        
        Phosphorylation of MDM4 by ATM (Mus musculus)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Deubiquitination (Mus musculus)
    - Ub-specific processing proteases (Mus musculus)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)
        
        USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Mus musculus)
        
        TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O35618

Gene Names

Mdm4

Reference Genes

BioGPS Gene:17248 Mdm4

ENSEMBL:ENSMUSG00000054387

KEGG:mmu:17248 Mdm4

Monarch:17248 Mdm4

NCBI Gene:17248 Mdm4

UCSC:O35618 Mdm4

Reference Transcript

Other Identifiers

10357773

108903_at

1419558_at

1453982_at

1460542_s_at

163238_f_at

17226953

17248

4323807

4329064

4357665

4363801

4391593

4403903

4422956

4470821

4642719

4661183

4677126

4713249

4765576

4767954

4844045

4868289

4877183

4941918

5043991

5080653

5083260

5101638

5109906

5127075

5133495

5158739

5173353

5207417

5225740

5244372

5268511

5277480

5293297

5321623

5345645

5346209

5415047

5423162

5425125

5485296

5488268

5527584

5557172

5605811

93338_at

93339_at

A_30_P01025208

A_30_P01026248

A_30_P01026618

A_30_P01028787

A_30_P01028801

A_30_P01030039

A_30_P01031221

A_30_P01032509

A_30_P01032561

A_30_P01032960

A_51_P176954

A_51_P258566

A_52_P174937

A_52_P485905

A_52_P596201

A_55_P2081388

A_55_P2617568

A_55_P2617573

A_55_P2716147

A_55_P2716152

GE1395710

GE34006

GO:0000122

GO:0002027

GO:0003170

GO:0003181

GO:0003203

GO:0003281

GO:0003283

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0008284

GO:0016567

GO:0016740

GO:0017053

GO:0019899

GO:0030330

GO:0042177

GO:0043066

GO:0043226

GO:0045892

GO:0046872

GO:0048856

GO:0050821

GO:0051726

GO:0065003

GO:0065008

GO:0071456

GO:0140096

GO:1902254

ILMN_1219311

ILMN_1227293

ILMN_1252838

ILMN_1257423

ILMN_2644167

ILMN_2877527

mMC014315

mMC020531

mMR027595

mMR027622

Participates

as a member of

as a component of

p-S166,S188-MDM2:MDM4 [nucleoplasm] (Mus musculus)

Other forms of this molecule

Mdm4 [nucleoplasm]

phospho-Mdm4 [nucleoplasm]

Inferred From

MDM4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001289731.1, NP_032601.2, NP_001289732.1, NP_001289730.1, NP_001289733.1

ENSEMBL

ENSMUSG00000054387, ENSMUST00000188090, ENSMUSP00000140609, ENSMUSP00000070411, ENSMUST00000067429

PRO

O35618

MGI

107934

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.641	4
UniProt:P02340 Tp53	20	TP53 [cytosol] (R-MMU-8869337) PolyUb-TP53 [nucleoplasm] (R-MMU-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-MMU-2997661) p- S18-Tp53 [nucleoplasm] (R-MMU-9816424) phospho-p-S15,S20-TP53 [nucleoplasm] (R-MMU-69683) phospho-p-S15-TP53 [nucleoplasm] (R-MMU-69507) TP53 [nucleoplasm] (R-MMU-69488) PolyUb-TP53 [cytosol] (R-MMU-6793681) PolyUb-TP53 [nucleoplasm] (R-MMU-6793679) phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-MMU-6804446) phospho-p-S15,S20,S46-TP53 [nucleoplasm] (R-MMU-6798369) phospho-p-T55-TP53 [nucleoplasm] (R-MMU-6805400) phospho-p-S15,S20,S392-TP53 [nucleoplasm] (R-MMU-6805053) phospho-p-S15,S33,S46-TP53 [nucleoplasm] (R-MMU-6805268) phospho-p-S15,S392-TP53 [nucleoplasm] (R-MMU-3222015) phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-MMU-6805133) phospho-p-S37-TP53 [nucleoplasm] (R-MMU-3239022) phospho-p-S315-TP53 [nucleoplasm] (R-MMU-6805106) phospho-p-S392-TP53 [nucleoplasm] (R-MMU-9836341) Me2K-370,382-TP53 [nucleoplasm] (R-MMU-3222242)	0.589	2
UniProt:P23804 Mdm2	12	PolyUb-MDM2 [nucleoplasm] (R-MMU-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-MMU-3000408) Mdm2 [cytosol] (R-MMU-9769903) MDM2 [plasma membrane] (R-MMU-416843) MDM2 [endocytic vesicle membrane] (R-MMU-416849) phospho-p-5S,T-MDM2 [nucleoplasm] (R-MMU-6804954) phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-MMU-6795669) phospho-p-S166,S188,T218-MDM2 [nucleoplasm] (R-MMU-6792862) MDM2 [nucleoplasm] (R-MMU-69486) MDM2 [cytosol] (R-MMU-198644) phospho-p-S166,S188-MDM2 [cytosol] (R-MMU-198638) phospho-p-S166,S188-MDM2 [nucleoplasm] (R-MMU-6793669)	0.564	2

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