Reactome | apoTF [extracellular region]

apoTF [extracellular region]

Stable Identifier

R-MMU-350754

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

Q921I1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - AP-2 directly binds some endocytic cargo (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        holoTF [extracellular region] (Mus musculus)
        
        apoTF [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:Q921I1

Reference Genes

BioGPS Gene:22041

CTD Gene:22041

ENSEMBL:ENSMUSG00000032554

KEGG:mmu:22041

Monarch:22041

NCBI Gene:22041

UCSC:Q921I1

Reference Transcript

RefSeq:NM_133977.2

Other Identifiers

10596148

1425546_a_at

17530243

22041

4358766

4408786

4486082

4597906

4658523

4708106

4767467

4789955

4797087

4800057

4848380

4875802

4892748

4950703

4967444

4990634

5040972

5063405

5175901

5194630

5234142

5326509

5426672

5466957

5495178

5495973

5499357

5566585

A_51_P362638

A_55_P2037584

A_55_P2037585

GE32952

GO:0002376

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0005768

GO:0005769

GO:0005770

GO:0005886

GO:0005905

GO:0006355

GO:0006826

GO:0006879

GO:0007015

GO:0008198

GO:0008199

GO:0009617

GO:0009925

GO:0009986

GO:0016020

GO:0016324

GO:0019731

GO:0019899

GO:0030120

GO:0030139

GO:0030154

GO:0030312

GO:0030316

GO:0030425

GO:0031012

GO:0031410

GO:0031643

GO:0031982

GO:0032436

GO:0034756

GO:0034986

GO:0042327

GO:0043226

GO:0044325

GO:0045178

GO:0045780

GO:0045893

GO:0046872

GO:0048260

GO:0048471

GO:0051286

GO:0055037

GO:0060586

GO:0070371

GO:0070447

GO:0071281

GO:0097433

GO:0098542

GO:0140104

GO:1990459

GO:1990712

GO:2000147

ILMN_2485323

mMC020059

Participates

as a member of

Platelet releasate secretory granule proteins [extracellular region] (Mus musculus)

as an output of

apo-Transferrin dissociates from the receptor complex (Mus musculus)

as an input of

apoTF binds 2Fe3+ to form holoTF (Mus musculus)

as a component of

Other forms of this molecule

apoTF [clathrin-coated endocytic vesicle membrane]

TF [secretory granule lumen]

apoTF [endosome membrane]

phospho-p-TF [endoplasmic reticulum lumen]

TF [endoplasmic reticulum lumen]

Inferred From

apoTF [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSP00000108264, ENSMUST00000112645, ENSMUSP00000035158, ENSMUST00000035158, ENSMUSG00000032554

PRO

Q921I1

GlyGen

Q921I1

MGI

98821

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16054	2	PRKCE [cytosol] (R-MMU-58202) phospho-p-T566,T710,S729-PRKCE [plasma membrane] (R-MMU-198260)	0.524	2

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