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phospho-p-6Y-PTK2 [cytosol]
Stable Identifier
R-MMU-354128
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P34152
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
NCAM signaling for neurite out-growth (Mus musculus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2 [cytosol] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2 [cytosol] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
FAK-SRC complex [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
FAK-SRC complex [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
phospho-p-6Y-PTK2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P34152 Ptk2
Gene Names
Ptk2, Fadk, Fak, Fak1, Kiaa4203
Chain
initiator methionine:, chain:2-1052
Participates
as a component of
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
FAK-SRC complex [plasma membrane] (Mus musculus)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2 [cytosol] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
phospho-p-Y194,Y397-PTK2 [cytosol]
phospho-pY-PTK2 [cytosol]
p-Y428-FAK1 [cytosol]
Fak1 [cytosol]
phospho-p-6Y,S732-PTK2 [cytosol]
phospho-p-5Y,S732-PTK2 [cytosol]
phospho-p-5Y-PTK2 [cytosol]
PTK2(773-1052) [cytosol]
PTK2(1-772) [cytosol]
PTK2 [cytosol]
phospho-p-Y397-PTK2 [cytosol]
Inferred From
p-6Y-PTK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 397 (in Homo sapiens)
Coordinate
397
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 576 (in Homo sapiens)
Coordinate
576
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 577 (in Homo sapiens)
Coordinate
577
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 861 (in Homo sapiens)
Coordinate
861
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 925 (in Homo sapiens)
Coordinate
925
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 407 (in Homo sapiens)
Coordinate
407
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8VI36
4
phospho-Pxn [plasma membrane]
(R-MMU-9031680)
Pxn [plasma membrane]
(R-MMU-180493)
Pxn [cytosol]
(R-MMU-210014)
phospho-Pxn [cytosol]
(R-MMU-5218693)
0.784
6
UniProt:Q61140 Bcar1
6
Bcar1 [cytosol]
(R-MMU-201625)
phospho-Bcar1 [cytosol]
(R-MMU-8848723)
phospho-Bcar1 [cytosol]
(R-MMU-5218739)
p130Cas [cytosol]
(R-MMU-5218743)
p-12Y-P130Cas [cytosol]
(R-MMU-5218727)
phospho-Bcar1 [cytosol]
(R-MMU-372645)
0.646
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.597
3
UniProt:P05480 Src
13
SRC-2 [cytosol]
(R-MMU-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-MMU-1810408)
SRC-1 [plasma membrane]
(R-MMU-65043)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-MMU-377598)
phospho-p-Y419-SRC [cytosol]
(R-MMU-377592)
Src [cytosol]
(R-MMU-418782)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-MMU-112331)
MyrG-SRC [plasma membrane]
(R-MMU-8876922)
phospho-p-Y419-SRC [cytosol]
(R-MMU-8964276)
SRC [cytosol]
(R-MMU-9628701)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
Activated Src [nucleoplasm]
(R-MMU-8937700)
p-Y416-Src [cytosol]
(R-MMU-8964306)
0.589
2
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.564
2
UniProt:Q60631 Grb2
1
Grb2 [cytosol]
(R-MMU-443287)
0.508
2
UniProt:Q99JY9
1
Actr3 [cytosol]
(R-MMU-200811)
0.463
2
UniProt:P54763 Ephb2
9
phospho-p-Y596,Y602-EPHB2 [plasma membrane]
(R-MMU-3928375)
p-Ephb2 [plasma membrane]
(R-MMU-3928433)
EPHB2 [plasma membrane]
(R-MMU-443809)
EPHB2 (19-?) [extracellular region]
(R-MMU-3928436)
EPHB2 (?-1055) [plasma membrane]
(R-MMU-3928386)
EPHB2 (?-1055) [cytosol]
(R-MMU-3928432)
P54763 [plasma membrane]
(R-MMU-3928394)
Ephb2 [plasma membrane]
(R-MMU-3928443)
p-Y604,Y610-Ephb2 [plasma membrane]
(R-MMU-4093312)
0.463
3
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.463
2
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