Reactome | Elmo2 [cytosol]

Elmo2 [cytosol]

Stable Identifier

R-MMU-372642

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ELMO2, Q8BHL5

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by PTK6 (Mus musculus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
      - Activation of RAC1 by the PXN:CRK complex (Mus musculus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
      - Phosphorylated PXN recruits the CRK complex (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - DOCK180:ELMO binds CRK (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase cycle (Mus musculus)
      - RHOG GTPase cycle (Mus musculus)
        
        RHOG binds effectors at the plasma membrane (Mus musculus)
        
        RHOG plasma membrane effectors [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Mus musculus)
        
        RHOG plasma membrane effectors [cytosol] (Mus musculus)
        
        Elmo2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BHL5

Gene Names

Elmo2

Reference Genes

BioGPS Gene:140579 Elmo2

ENSEMBL:ENSMUSG00000017670

ENSEMBL:ENSMUSG00000017670.17 Elmo2

KEGG Gene (Mus musculus):140579 Elmo2

Monarch:140579 Elmo2

NCBI Gene:140579 Elmo2

UCSC:Q8BHL5 Elmo2

Reference Transcript

Other Identifiers

10489660

105329_at

111833_at

140579

1436011_at

1456098_a_at

17394405

4352064

4356548

4391288

4458275

4486062

4494608

4512407

4525115

4539328

4629308

4731417

4806533

4813020

4873795

4887561

4947271

4957378

4974509

5029201

5058709

5064834

5067831

5105109

5124704

5138160

5142203

5147691

5168413

5187955

5211841

5250320

5336287

5392900

5413298

5433668

5463649

5463717

5492084

5552209

A_51_P199382

A_52_P620357

GE126231

GO:0005737

GO:0005829

GO:0006909

GO:0006915

GO:0007010

GO:0007015

GO:0012501

GO:0016020

GO:0016192

GO:0017124

GO:0030971

GO:0048870

GO:0060326

ILMN_2587785

ILMN_2708469

ILMN_3058341

ILMN_3135409

mMC018347

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Mus musculus)

as a member of

ELMO1,ELMO2 [cytosol] (Mus musculus)

Inferred From

ELMO2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017170976.1, NP_001289681.1, XP_011237587.1, XP_011237586.1, NP_001289683.1, NP_997589.1, NP_525026.2, XP_011237588.1

Ensembl

ENSMUST00000103088, ENSMUST00000094329, ENSMUST00000071699, ENSMUST00000074046, ENSMUSP00000099380, ENSMUST00000103091, ENSMUSP00000099377, ENSMUSG00000017670, ENSMUSP00000071619, ENSMUSP00000073691, ENSMUSP00000091887

PRO

Q8BHL5

MGI

2153045

PDB

6UKA