Reactome | Ube2i [nucleoplasm]

Ube2i [nucleoplasm]

Stable Identifier

R-MMU-3730617

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

SUMO1-C93-UBE2I, P63280

Locations in the PathwayBrowser

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DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - DNA Double Strand Break Response (Mus musculus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Mus musculus)
        
        SUMO1:C93-UBE2I [nucleoplasm] (Mus musculus)
        
        Ube2i [nucleoplasm] (Mus musculus)
- Nucleotide Excision Repair (Mus musculus)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
    - Formation of Incision Complex in GG-NER (Mus musculus)
      - SUMOylation of XPC (Mus musculus)
        
        SUMO1,2,3:UBE2I [nucleoplasm] (Mus musculus)
        
        SUMO1:C93-UBE2I [nucleoplasm] (Mus musculus)
        
        Ube2i [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Mus musculus)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Mus musculus)
        
        SUMOylation of TFAP2C with SUMO1 (Mus musculus)
        
        SUMO1:C93-UBE2I [nucleoplasm] (Mus musculus)
        
        Ube2i [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P63280 Ube2i

Gene Names

Ube2i, Ubc9, Ubce2i, Ubce9

Chain

initiator methionine:, chain:2-158

Reference Genes

BioGPS Gene:22196 Ube2i

KEGG:mmu:22196 Ube2i

Monarch:22196 Ube2i

NCBI Gene:22196 Ube2i

UCSC:P63280 Ube2i

Reference Transcript

Other Identifiers

10448912

10478012

10598636

107897_at

133474_at

1422712_a_at

1422713_a_at

1422714_at

1425478_x_at

1429545_at

1436457_at

1453189_at

17342219

22196

4363964

4371453

4393366

4417409

4486178

4517816

4549465

4559775

4588862

4596401

4630922

4636767

4759668

4764201

4771206

4897603

4901620

4920336

4943594

4971430

4973579

4988327

4996370

5000153

5097726

5157053

5173224

5230168

5246213

5270223

5319148

5360075

5441357

5605693

97530_at

A_51_P366406

A_51_P400909

A_52_P1067

A_52_P269595

A_52_P297731

A_52_P369112

A_55_P1980543

A_55_P1984721

A_55_P2114915

A_55_P2326517

A_66_P132625

GE36858

GO:0000122

GO:0001221

GO:0001650

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006913

GO:0007059

GO:0016604

GO:0016605

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0030335

GO:0030425

GO:0035255

GO:0036211

GO:0043123

GO:0043226

GO:0043398

GO:0043425

GO:0044388

GO:0045892

GO:0050804

GO:0051168

GO:0051301

GO:0061656

GO:0071535

GO:0098685

GO:0098978

GO:0099523

GO:0099524

GO:0106068

GO:0140096

GO:1990234

ILMN_2417991

ILMN_2499058

ILMN_2518142

ILMN_2786360

mMC019519

mMR028357

mMR028452

Participates

as a component of

SUMO1:C93-UBE2I [nucleoplasm] (Mus musculus)

Other forms of this molecule

Ube2i [nucleoplasm]

Ube2i [cytosol]

Ube2i [nucleoplasm]

Ube2i [cytosol]

Sumo1-C93-Ube2i [nucleoplasm]

Sumo3-C93-Ube2i [nucleoplasm]

Sumo2-C93-Ube2i [nucleoplasm]

Ube2i [nuclear envelope]

Ube2i [nucleoplasm]

Inferred From

SUMO1-C93-UBE2I [nucleoplasm] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 93 and 97 (in Homo sapiens)

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001171080.1, NP_001171081.1, XP_006524111.1, NP_035795.1, XP_006524112.1

ENSEMBL

ENSMUSP00000134450, ENSMUSP00000134261, ENSMUSP00000134350, ENSMUST00000173713, ENSMUSP00000055714, ENSMUST00000174001, ENSMUST00000173084, ENSMUST00000174031, ENSMUSP00000134491, ENSMUST00000049911

PRO

P63280

MGI

107365

PDB

2UYZ, 2VRR, 1U9B, 1U9A

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q505F1 Nr2c1	3	monoSumo1-K238-Nr2c1 [nucleoplasm] (R-MMU-4717500) Nr2c1 [nucleoplasm] (R-MMU-4717495) Nr2c1 [nucleoplasm] (R-MMU-376211)	0.593	3
UniProt:P08152 Egr2	2	Egr2 [nucleoplasm] (R-MMU-977395) Egr2 [nucleoplasm] (R-MMU-977385)	0.527	2