Reactome | Sstr2 [plasma membrane]

Sstr2 [plasma membrane]

Stable Identifier

R-MMU-374757

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

SSTR2, P30875

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Peptide ligand-binding receptors (Mus musculus)
        
        Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P30875

Gene Names

Sstr2

Reference Genes

BioGPS Gene:20606 Sstr2

ENSEMBL:ENSMUSG00000047904

KEGG Gene (Mus musculus):20606 Sstr2

Monarch:20606 Sstr2

NCBI Gene:20606 Sstr2

UCSC:P30875 Sstr2

Reference Transcript

Other Identifiers

10382341

1422256_at

17257962

20606

4706770

5003911

5189802

5247090

5482763

5506977

98350_at

98351_g_at

98352_r_at

A_51_P238165

A_55_P2065424

GE33691

GO:0003012

GO:0004930

GO:0004994

GO:0005737

GO:0005829

GO:0005886

GO:0006937

GO:0007165

GO:0007186

GO:0007193

GO:0007218

GO:0007283

GO:0016020

GO:0021549

GO:0022414

GO:0023052

GO:0030165

GO:0030432

GO:0030900

GO:0038170

GO:0042594

GO:0043005

GO:0048856

GO:0060089

GO:0071385

GO:0071392

ILMN_1229577

ILMN_3106619

X68951_s_at

mMC009952

Participates

as a member of

Somatostatin receptors [plasma membrane] (Mus musculus)

Inferred From

SSTR2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_033243.2, NP_001036071.1

ZINC - Substances

SSR2_MOUSE

ZINC target

P30875

Ensembl

ENSMUST00000146390, ENSMUSG00000047904, ENSMUSP00000068578, ENSMUSP00000138101, ENSMUSP00000102241, ENSMUST00000106630, ENSMUST00000067591

PRO

P30875

MGI

98328

ZINC - Predictions - Purchasable

SSR2_MOUSE

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	2