Reactome | Cenpo [cytosol]

Cenpo [cytosol]

Stable Identifier

R-MMU-375301

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CENPO, Q8K015

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpo [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K015

Gene Names

Cenpo

Reference Genes

BioGPS Gene:52504 Cenpo

ENSEMBL:ENSMUSG00000020652

ENSEMBL:ENSMUSG00000020652.18 Cenpo

KEGG Gene (Mus musculus):52504 Cenpo

Monarch:52504 Cenpo

NCBI Gene:52504 Cenpo

UCSC:Q8K015 Cenpo

Reference Transcript

Other Identifiers

10399254

113015_at

1418541_at

1418542_s_at

1453991_at

1459119_at

17279789

4418933

4425198

4660043

4768441

4786325

4884393

4894545

4901543

4915495

4985121

5058519

5094468

5130004

5148699

52504

5317087

5406123

5446475

5515356

99519_at

A_51_P121275

A_52_P468711

A_55_P2165774

GE128012

GO:0000775

GO:0000776

GO:0000939

GO:0003674

GO:0005634

GO:0005654

GO:0005694

GO:0007059

GO:0008150

GO:0016604

GO:0031511

GO:0034508

GO:0043226

GO:0065003

ILMN_1251280

ILMN_1256744

ILMN_2628786

ILMN_2650860

ILMN_2768773

ILMN_2887846

mMC026236

mMR001174

Participates

as a component of

CENP-O complex [cytosol] (Mus musculus)

Other forms of this molecule

Cenpo [nucleoplasm]

Inferred From

CENPO [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006515215.1, NP_598807.2, XP_011242186.1

Ensembl

ENSMUST00000140975, ENSMUSP00000106799, ENSMUST00000111169, ENSMUSG00000020652, ENSMUSP00000119136

PRO

Q8K015

MGI

1923800

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