Reactome | Cenpu [cytosol]

Cenpu [cytosol]

Stable Identifier

R-MMU-375315

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

MLF1IP, Q8C4M7

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Cenpu [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8C4M7

Gene Names

Cenpu

Reference Genes

BioGPS Gene:71876 Cenpu

ENSEMBL:ENSMUSG00000031629

ENSEMBL:ENSMUSG00000031629.15 Cenpu

KEGG Gene (Mus musculus):71876 Cenpu

Monarch:71876 Cenpu

NCBI Gene:71876 Cenpu

UCSC:Q8C4M7 Cenpu

Reference Transcript

RefSeq:NM_027973.3 Cenpu

Other Identifiers

10571680

106056_at

1428518_at

1452816_at

17501025

4504614

4561759

4579279

4724449

4731059

4755682

4781961

4808450

4881904

4921167

4950528

4953632

4977839

5041082

5125525

5335866

5371054

5414268

5414564

5436365

5485896

71876

A_51_P241791

A_52_P415931

A_55_P1988373

GE38978

GO:0000775

GO:0000776

GO:0000939

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005815

GO:0005856

GO:0007059

GO:0034451

GO:0043009

GO:0043226

GO:0048856

ILMN_2642654

mMC005456

Participates

as a component of

CENP-O complex [cytosol] (Mus musculus)

Other forms of this molecule

Cenpu [nucleoplasm]

Inferred From

MLF1IP [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_082249.1

Ensembl

ENSMUST00000034045, ENSMUSP00000034045, ENSMUSP00000091239, ENSMUST00000093518, ENSMUSG00000031629

PRO

Q8C4M7

MGI

1919126

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