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Ncoa2 [nucleoplasm]
Stable Identifier
R-MMU-376398
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
NCOA2, Q61026
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Cytoprotection by HMOX1 (Mus musculus)
Fatty acid ligands activate PPARA (Mus musculus)
Coactivators of PPARalpha [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
PPARA:RXRA Coactivator complex [nucleoplasm] (Mus musculus)
Coactivators of PPARalpha [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Cytochrome P450 - arranged by substrate type (Mus musculus)
Endogenous sterols (Mus musculus)
CYP7A1 7-hydroxylates CHOL (Mus musculus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Bile acid and bile salt metabolism (Mus musculus)
Recycling of bile acids and salts (Mus musculus)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Mus musculus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Synthesis of bile acids and bile salts (Mus musculus)
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Mus musculus)
27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Mus musculus)
CYP7A1 7-hydroxylates CHOL (Mus musculus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Regulation of lipid metabolism by PPARalpha (Mus musculus)
Fatty acid ligands activate PPARA (Mus musculus)
Coactivators of PPARalpha [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
PPARA:RXRA Coactivator complex [nucleoplasm] (Mus musculus)
Coactivators of PPARalpha [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Estrogen-dependent gene expression (Mus musculus)
HATs and coactivators are recruited to the CTSD gene (Mus musculus)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Mus musculus)
NCOAs [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
NCOAs [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases activate PKNs (Mus musculus)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Mus musculus)
PKN1 stimulates association of AR with NCOA2 (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
p-T774-PKN1:AR:Androgen:NCOA2 [nucleoplasm] (Mus musculus)
Ncoa2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q61026 Ncoa2
Gene Names
Ncoa2, Grip1, Src2, Tif2
Chain
initiator methionine:, chain:2-1462
Reference Genes
BioGPS Gene:17978 Ncoa2
ENSEMBL:ENSMUSG00000005886.15 Ncoa2
KEGG Gene (Mus musculus):17978 Ncoa2
Monarch:17978 Ncoa2
NCBI Gene:17978 Ncoa2
UCSC:Q61026 Ncoa2
Reference Transcript
RefSeq:NM_008678.3 Ncoa2
RefSeq:XM_006495465.3 Ncoa2
Other Identifiers
10353135
1450458_at
17221317
17978
4361294
4373842
4402121
4428402
4746471
4824313
4837225
4916590
4944228
4975195
5018280
5066214
5106353
5116742
5124381
5132785
5167860
5173108
5226533
5249418
5269820
5352622
5370741
5417259
5428435
5605665
96508_at
GE34082
GO:0000122
GO:0000978
GO:0001162
GO:0003677
GO:0003682
GO:0003713
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005975
GO:0006351
GO:0006355
GO:0006629
GO:0007623
GO:0010468
GO:0010906
GO:0016071
GO:0016604
GO:0016922
GO:0017162
GO:0019216
GO:0019904
GO:0022414
GO:0023052
GO:0030331
GO:0030374
GO:0032570
GO:0032870
GO:0032922
GO:0032991
GO:0035259
GO:0035357
GO:0042789
GO:0042974
GO:0043197
GO:0043226
GO:0044877
GO:0045475
GO:0045892
GO:0045925
GO:0045944
GO:0046965
GO:0046966
GO:0046983
GO:0048511
GO:0048856
GO:0061629
GO:0070182
GO:0090575
GO:0140110
GO:1900076
GO:1904017
GO:1904179
GO:2000324
ILMN_1256574
ILMN_1259910
mMR030917
u39060_s_at
Participates
as a candidate of
NCOAs [nucleoplasm] (Mus musculus)
as a member of
NCOAs (PPARG,RXRA) [nucleoplasm] (Mus musculus)
Coactivators of PPARalpha [nucleoplasm] (Mus musculus)
as an input of
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)
PKN1 stimulates association of AR with NCOA2 (Mus musculus)
as a component of
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Mus musculus)
p-T774-PKN1:AR:Androgen:NCOA2 [nucleoplasm] (Mus musculus)
Other forms of this molecule
monoSUMO1-K239,K731,K788-Ncoa2 [nucleoplasm]
Ncoa2 [nucleoplasm]
Ncoa2 [nucleoplasm]
Inferred From
NCOA2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006495528.1
,
NP_032704.2
Ensembl
ENSMUST00000006037
,
ENSMUSG00000005886
,
ENSMUSP00000006037
PRO
Q61026
MGI
1276533
PDB
3MNE
,
2QA8
,
1L2I
,
1WM0
,
2QZO
,
3MNP
,
2QPY
,
2QAB
,
2QR9
,
2QA6
,
2QXM
,
2Q6J
,
3MNO
,
2QH6
,
1OSV
,
2QGW
,
2QSE
,
2QGT
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q4FZB7-1 KMT5B
0.59
4
ChEBI:73676 3-DEOXYCHENODEOXYCHOLIC ACID
0.558
2
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