Reactome | Dctn2 [cytosol]

Dctn2 [cytosol]

Stable Identifier

R-MMU-380302

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

DCTN2, Q99KJ8

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Transport of antigen loaded MHC II molecules to surface (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - Kinesins:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPI-mediated anterograde transport (Mus musculus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)

Organelle biogenesis and maintenance (Mus musculus)

- Cilium Assembly (Mus musculus)
  - Anchoring of the basal body to the plasma membrane (Mus musculus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
    - C2CD3 binds the mother centriole (Mus musculus)
      - mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)
      - basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
    - CP110 and CEP97 dissociate from the centriole (Mus musculus)
      - basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
    - MARK4 binds ODF2 in the centriole (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
    - Recruitment of transition zone proteins (Mus musculus)
      - basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
    - The distal appendage proteins recruit TTBK2 (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPI-mediated anterograde transport (Mus musculus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
    - Golgi-to-ER retrograde transport (Mus musculus)
      - COPI-independent Golgi-to-ER retrograde traffic (Mus musculus)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin arm [cytosol] (Mus musculus)
        
        Dynactin shoulder [cytosol] (Mus musculus)
        
        Dynamitin tetramer [cytosol] (Mus musculus)
        
        Dctn2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q99KJ8

Gene Names

Dctn2

Reference Genes

BioGPS Gene:69654 Dctn2

ENSEMBL:ENSMUSG00000025410

KEGG:mmu:69654 Dctn2

Monarch:69654 Dctn2

NCBI Gene:69654 Dctn2

UCSC:Q99KJ8 Dctn2

Reference Transcript

RefSeq:NM_027151.2 Dctn2

Other Identifiers

10366866

1424461_at

17237958

4319853

4336993

4352153

4357323

4400288

4419140

4490437

4497681

4590178

4644054

4680346

4697879

4726933

4749173

4773277

4842511

4868665

5078599

5203127

5261211

5270047

5283600

5303461

5390237

5427079

5447286

5477510

5498733

5516005

5530738

5553739

5566470

5604593

69654

94299_at

94300_f_at

A_51_P435333

A_55_P2776637

GE39384

GO:0000776

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0005869

GO:0005874

GO:0007010

GO:0007017

GO:0007052

GO:0007080

GO:0008092

GO:0016020

GO:0019901

GO:0030286

GO:0030426

GO:0030507

GO:0031982

GO:0032402

GO:0042802

GO:0043226

GO:0071539

ILMN_2679063

ILMN_2707623

ILMN_2859659

mMC022470

mMR027917

Participates

as a component of

Inferred From

DCTN2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_081427.1

ENSEMBL

ENSMUSG00000025410, ENSMUST00000026479, ENSMUSP00000026479

PRO

Q99KJ8

GlyGen

Q99KJ8

MGI

107733

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14203 DCTN1	7	DCTN1 [cytosol] (R-HSA-535580) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969)	0.564	2

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