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EP300 [nucleoplasm]
Stable Identifier
R-MMU-381325
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
B2RWS6
Locations in the PathwayBrowser for interactor IntAct:EBI-4566324 IL17
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Regulation of gene expression by Hypoxia-inducible Factor (Mus musculus)
Formation of HIF:CBP:p300 complex at promoters (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
Epigenetic regulation of gene expression (Mus musculus)
Positive epigenetic regulation of rRNA expression (Mus musculus)
B-WICH complex positively regulates rRNA expression (Mus musculus)
B-WICH recruits histone acetyltransferases (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Acetylation (Mus musculus)
BRD7 binds TP53 and EP300 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
PI5P Regulates TP53 Acetylation (Mus musculus)
ING2 recruits EP300 to TP53 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Regulation of TP53 Activity through Methylation (Mus musculus)
JMY, TTC5 and EP300 bind (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Transcriptional regulation by RUNX1 (Mus musculus)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Mus musculus)
RUNX1:CBFB binds EP300 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Transcriptional regulation by RUNX3 (Mus musculus)
RUNX3 regulates p14-ARF (Mus musculus)
CCND1 binds RUNX3 and displaces EP300 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
RUNX3 binds EP300 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Regulation of RUNX3 expression and activity (Mus musculus)
SMURFs ubiquitinate RUNX3 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Mus musculus)
Activation of the TFAP2 (AP-2) family of transcription factors (Mus musculus)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
SUMOylation (Mus musculus)
SUMO E3 ligases SUMOylate target proteins (Mus musculus)
SUMOylation of transcription cofactors (Mus musculus)
SUMOylation of EP300 with SUMO1 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by NOTCH (Mus musculus)
Signaling by NOTCH1 (Mus musculus)
NOTCH1 Intracellular Domain Regulates Transcription (Mus musculus)
NICD1 in complex with RBPJ (CSL) recruits MAML (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Estrogen-dependent gene expression (Mus musculus)
CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
EP300 is recruited to MYC and BCL2 genes (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
GREB1 binds ESR1:ESTG and co-activators (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
HATs and coactivators are recruited to the CTSD gene (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
NCOA1 recruits EP300 to TGFA promoter (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
NR1H2 and NR1H3-mediated signaling (Mus musculus)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Mus musculus)
NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
STAT3 nuclear events downstream of ALK signaling (Mus musculus)
p-Y705,S727 STAT3 is acetylated (Mus musculus)
EP300 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:B2RWS6 Ep300
Gene Names
Ep300, P300
Chain
initiator methionine:, chain:2-2412
Reference Genes
BioGPS Gene:328572 Ep300
KEGG:mmu:328572 Ep300
Monarch:328572 Ep300
NCBI Gene:328572 Ep300
UCSC:B2RWS6 Ep300
Reference Transcript
RefSeq:NM_177821.6 Ep300
Other Identifiers
10425527
115567_r_at
115637_at
1434765_at
17313284
328572
4356786
4395476
4434206
4450029
4467506
4473831
4497604
4551140
4589749
4596339
4618654
4622082
4625978
4628377
4652070
4660620
4671002
4710450
4734625
4734663
4744912
4746787
4758009
4759867
4797275
4815721
4856314
4870621
4910340
4916007
4933683
4964798
4967661
4991463
5107448
5116991
5129382
5147868
5163242
5167749
5168726
5171470
5245036
5246980
5300848
5316115
5365173
5383069
5384292
5444715
5447608
5458191
5479583
5510538
5512708
5556041
5556660
5558476
5598940
A_51_P142128
A_51_P304029
A_52_P179662
A_52_P411601
A_55_P2720903
GE128705
GE1470834
GO:0000122
GO:0000123
GO:0000785
GO:0000978
GO:0000987
GO:0001221
GO:0001223
GO:0001666
GO:0001756
GO:0001934
GO:0001966
GO:0002039
GO:0002209
GO:0002376
GO:0003677
GO:0003682
GO:0003684
GO:0003712
GO:0003713
GO:0003723
GO:0003823
GO:0003824
GO:0004402
GO:0004468
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0006110
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006473
GO:0006475
GO:0006915
GO:0007249
GO:0007507
GO:0007519
GO:0007611
GO:0007623
GO:0008013
GO:0008270
GO:0009410
GO:0009749
GO:0009887
GO:0010484
GO:0010485
GO:0010507
GO:0010560
GO:0010628
GO:0010821
GO:0010976
GO:0012501
GO:0014737
GO:0016407
GO:0016740
GO:0016746
GO:0016922
GO:0018076
GO:0019901
GO:0030154
GO:0030183
GO:0030220
GO:0030307
GO:0030324
GO:0030511
GO:0031333
GO:0031490
GO:0031648
GO:0031669
GO:0032967
GO:0032991
GO:0032993
GO:0034644
GO:0035259
GO:0035264
GO:0035855
GO:0036211
GO:0036268
GO:0042307
GO:0042771
GO:0042975
GO:0043226
GO:0043425
GO:0043627
GO:0043923
GO:0043993
GO:0044013
GO:0044017
GO:0044877
GO:0045444
GO:0045721
GO:0045727
GO:0045773
GO:0045793
GO:0045815
GO:0045862
GO:0045893
GO:0045944
GO:0046332
GO:0046427
GO:0046872
GO:0048511
GO:0048856
GO:0050681
GO:0050714
GO:0050821
GO:0050877
GO:0051019
GO:0051059
GO:0051091
GO:0051216
GO:0051592
GO:0051604
GO:0060090
GO:0060177
GO:0060298
GO:0060325
GO:0060765
GO:0061051
GO:0061629
GO:0061733
GO:0061920
GO:0061921
GO:0065003
GO:0065004
GO:0071233
GO:0071347
GO:0071548
GO:0090043
GO:0097157
GO:0097677
GO:0106226
GO:0120300
GO:0120301
GO:0140033
GO:0140064
GO:0140065
GO:0140066
GO:0140067
GO:0140068
GO:0140069
GO:0140096
GO:0140110
GO:0140297
GO:0140908
GO:1900039
GO:1901300
GO:1901985
GO:1904263
GO:1990405
GO:1990841
GO:2000330
GO:2000629
ILMN_1220783
ILMN_2479839
ILMN_2561221
ILMN_2625134
ILMN_2800358
mMC015381
mMR030506
Participates
as a component of
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Mus musculus)
NOTCH1 Coactivator Complex [nucleoplasm] (Mus musculus)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Mus musculus)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Mus musculus)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Mus musculus)
ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Mus musculus)
p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Mus musculus)
HIF:CBP:p300 [nucleoplasm] (Mus musculus)
TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] (Mus musculus)
Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] (Mus musculus)
RUNX3:CBFB:EP300 [nucleoplasm] (Mus musculus)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
RUNX1:CBFB:EP300 [nucleoplasm] (Mus musculus)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Mus musculus)
MYSM1:EP300:KAT2B [nucleoplasm] (Mus musculus)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Mus musculus)
ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] (Mus musculus)
CITED1:EP300:ESR1:estrogen:TGFA gene promoter [nucleoplasm] (Mus musculus)
TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] (Mus musculus)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Mus musculus)
ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 [nucleoplasm] (Mus musculus)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Mus musculus)
GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] (Mus musculus)
as an input of
NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)
GREB1 binds ESR1:ESTG and co-activators (Mus musculus)
NICD1 in complex with RBPJ (CSL) recruits MAML (Mus musculus)
BRD7 binds TP53 and EP300 (Mus musculus)
ING2 recruits EP300 to TP53 (Mus musculus)
JMY, TTC5 and EP300 bind (Mus musculus)
Formation of HIF:CBP:p300 complex at promoters (Mus musculus)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Mus musculus)
RUNX3 binds EP300 (Mus musculus)
RUNX1:CBFB binds EP300 (Mus musculus)
B-WICH recruits histone acetyltransferases (Mus musculus)
SUMOylation of EP300 with SUMO1 (Mus musculus)
EP300 is recruited to MYC and BCL2 genes (Mus musculus)
NCOA1 recruits EP300 to TGFA promoter (Mus musculus)
CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)
ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)
HATs and coactivators are recruited to the CTSD gene (Mus musculus)
as an output of
CCND1 binds RUNX3 and displaces EP300 (Mus musculus)
as a member of
histone acetyltransferases [nucleoplasm] (Mus musculus)
CREBBP,EP300 [nucleoplasm] (Mus musculus)
as a candidate of
KAT2B,(EP300) [nucleoplasm] (Mus musculus)
This entity regulates
Negatively
SMURFs ubiquitinate RUNX3
(Mus musculus)
Other forms of this molecule
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
phospho-p-S,T-EP300 [nucleoplasm]
Ep300 [nucleoplasm]
Inferred From
EP300 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_808489.4
ENSEMBL
ENSMUST00000068387
,
ENSMUSP00000066789
IntEnz
2.3.1.48
PRO
B2RWS6
GlyGen
B2RWS6
MGI
1276116
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02340 Tp53
20
TP53 [cytosol]
(R-MMU-8869337)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-MMU-2997661)
p- S18-Tp53 [nucleoplasm]
(R-MMU-9816424)
phospho-p-S15,S20-TP53 [nucleoplasm]
(R-MMU-69683)
phospho-p-S15-TP53 [nucleoplasm]
(R-MMU-69507)
TP53 [nucleoplasm]
(R-MMU-69488)
PolyUb-TP53 [cytosol]
(R-MMU-6793681)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6793679)
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6804446)
phospho-p-S37-TP53 [nucleoplasm]
(R-MMU-3239022)
phospho-p-T55-TP53 [nucleoplasm]
(R-MMU-6805400)
phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-MMU-6805133)
phospho-p-S15,S20,S46-TP53 [nucleoplasm]
(R-MMU-6798369)
phospho-p-S15,S392-TP53 [nucleoplasm]
(R-MMU-3222015)
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
(R-MMU-6805268)
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
(R-MMU-6805053)
phospho-p-S315-TP53 [nucleoplasm]
(R-MMU-6805106)
phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-5628868)
phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6805631)
0.702
3
IntAct:EBI-4566324 IL17
0.527
2
UniProt:A0A087WPF7
1
Auts2 [nucleoplasm]
(R-MMU-8937967)
0.499
3
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