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phospho CD28:B7-1/B7-2 [plasma membrane]
Stable Identifier
R-MMU-388777
Type
Complex
Species
Mus musculus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
PI3K binds CD28 (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
CD28 dependent Vav1 pathway (Mus musculus)
Activation of Cdc42 by pVav1 (Mus musculus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
Activation of Rac1 by pVav1 (Mus musculus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
Activation of Vav1 (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
Grb2 binds CD28 (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
Translocation of Vav1 to CD28 (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
Gads binds CD28 (Mus musculus)
CD28:GRAP2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
Phosphorylation of CD28 (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
B7-1 homodimer/ B7-2 [plasma membrane]
(Mus musculus)
x 2
FYN,LCK [cytosol]
(Mus musculus)
Phospho CD28 homodimer [plasma membrane]
(Mus musculus)
Participates
as an input of
Gads binds CD28 (Mus musculus)
Grb2 binds CD28 (Mus musculus)
PI3K binds CD28 (Mus musculus)
as a component of
CD28:GRAP2 [plasma membrane] (Mus musculus)
CD28:Grb2 [plasma membrane] (Mus musculus)
CD28:PI3K [plasma membrane] (Mus musculus)
as an output of
Phosphorylation of CD28 (Mus musculus)
Inferred From
phospho CD28:B7-1/B7-2 [plasma membrane]
(Homo sapiens)
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