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phospho-p-S144,T423-PAK1 [cytosol]
Stable Identifier
R-MMU-399819
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
O88643
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
L1CAM interactions (Mus musculus)
Signal transduction by L1 (Mus musculus)
Interaction of PAK1 with Rac1-GTP (Mus musculus)
pPAK1:Rac1-GTP [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Semaphorin interactions (Mus musculus)
Sema3A PAK dependent Axon repulsion (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Phosphorylation of LIMK-1 by PAK (Mus musculus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
p-2Y-PAK [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Autophosphorylation of PAK1 (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
PAK1 phosphorylates LIMK1 (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Muscle contraction (Mus musculus)
Smooth Muscle Contraction (Mus musculus)
MYLK (MLCK) Active Calmodulin Binding (Mus musculus)
p-S,T-PAK1,2 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
PAK1,2,3 phosphorylates MAPK6,4 (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
PAK1-3 autophosphorylates (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
PAK1-3 phosphorylates VE-cadherin (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases activate PAKs (Mus musculus)
Autophosphorylation of PAK1,2,3 (Mus musculus)
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
FLNA binds PAK1 (Mus musculus)
p-S144,T423-PAK1:FLNA [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
MYLK (MLCK) Active Calmodulin Binding (Mus musculus)
p-S,T-PAK1,2 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
PAK1 or PAK2 phosphorylates MYLK (Mus musculus)
p-S,T-PAK1,2 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
PAK1 phosphorylates FLNA (Mus musculus)
p-S144,T423-PAK1:FLNA [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
PAK1 phosphorylates LIMK1 (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
PAK1 phosphorylates myosin phosphatase (Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O88643
Reference Genes
ENSEMBL:ENSMUSG00000030774
Participates
as a component of
pPAK1:Rac1-GTP [cytosol] (Mus musculus)
p-S144,T423-PAK1:FLNA [cytosol] (Mus musculus)
as an output of
PAK1 phosphorylates FLNA (Mus musculus)
Autophosphorylation of PAK1 (Mus musculus)
as an input of
FLNA binds PAK1 (Mus musculus)
as a member of
p-S,T-PAK1,2,3 [cytosol] (Mus musculus)
p-2Y-PAK [cytosol] (Mus musculus)
as a candidate of
p-S,T-PAK1,2 [cytosol] (Mus musculus)
Other forms of this molecule
PAK1 [plasma membrane]
phospho-p-S144,T423-PAK1 [plasma membrane]
PAK1 [cytosol]
Inferred From
p-S144,T423-PAK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 144 (in Homo sapiens)
Coordinate
144
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 423 (in Homo sapiens)
Coordinate
423
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
PRO
O88643
MGI
1339975
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60766 Cdc42
3
CDC42 [endoplasmic reticulum membrane]
(R-MMU-5672086)
Cdc42 [plasma membrane]
(R-MMU-448841)
CDC42 [cytosol]
(R-MMU-442630)
0.589
2
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