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pFyn (420) [cytosol]
Stable Identifier
R-MMU-420335
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
NCAM signaling for neurite out-growth (Mus musculus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
NCAM:pFyn-Y420 [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
NCAM:pFyn-Y420 [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Mus musculus)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
NCAM:pFyn-Y420 [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
NCAM:pFyn-Y420 [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
NCAM:pFyn-Y420 [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
NCAM:pFyn-Y420 [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
FYN autophosphorylates (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
p-Y420-FYN is phosphorylated on S21 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Mus musculus)
pFyn (420) [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P39688 Fyn
Gene Names
Fyn
Chain
initiator methionine:, chain:2-537
Reference Genes
BioGPS Gene:14360 Fyn
ENSEMBL:ENSMUSG00000019843.15 Fyn
KEGG Gene (Mus musculus):14360 Fyn
Monarch:14360 Fyn
NCBI Gene:14360 Fyn
UCSC:P39688 Fyn
Reference Transcript
RefSeq:XM_006512540.3 Fyn
RefSeq:NM_001122893.1 Fyn
RefSeq:XM_006512539.3 Fyn
RefSeq:NM_001122892.1 Fyn
RefSeq:NM_008054.2 Fyn
RefSeq:XM_011243117.2 Fyn
Other Identifiers
100133_at
10362596
1417558_at
14360
1448765_at
17232649
4314829
4397041
4466414
4541435
4580322
4654065
4676338
4715314
4725505
4743495
4781355
4858624
4940270
4945244
4963615
5066773
5108731
5151999
5281641
5312172
5529442
5554180
5559307
A_66_P138915
GO:0000166
GO:0000304
GO:0001664
GO:0001764
GO:0002250
GO:0002376
GO:0003013
GO:0003015
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005783
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0006468
GO:0006886
GO:0007166
GO:0007169
GO:0008092
GO:0008360
GO:0010629
GO:0010730
GO:0010976
GO:0012501
GO:0014069
GO:0015631
GO:0016004
GO:0016020
GO:0016301
GO:0016310
GO:0016567
GO:0016740
GO:0018108
GO:0019899
GO:0023052
GO:0030154
GO:0030163
GO:0030425
GO:0030900
GO:0031175
GO:0031234
GO:0031397
GO:0031410
GO:0031802
GO:0034330
GO:0035556
GO:0036120
GO:0036211
GO:0042177
GO:0042531
GO:0042552
GO:0042608
GO:0042609
GO:0042610
GO:0042802
GO:0043014
GO:0043204
GO:0043226
GO:0043274
GO:0043524
GO:0043548
GO:0044297
GO:0044325
GO:0044877
GO:0045087
GO:0045121
GO:0045471
GO:0046872
GO:0046875
GO:0048156
GO:0048471
GO:0048813
GO:0048856
GO:0048870
GO:0050730
GO:0050798
GO:0050804
GO:0050852
GO:0050877
GO:0050966
GO:0051428
GO:0051897
GO:0055085
GO:0070301
GO:0070851
GO:0071560
GO:0071944
GO:0090314
GO:0097038
GO:0097110
GO:0097386
GO:0097718
GO:0098542
GO:0098685
GO:0098772
GO:0098978
GO:0099092
GO:0140096
GO:1900182
GO:1900449
GO:1902176
GO:1902951
GO:1904645
GO:1904646
GO:1905232
GO:1905430
GO:1905664
GO:2001240
ILMN_2663821
ILMN_2730490
ILMN_2751207
mMC016479
u70324_s_at
Participates
as a component of
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Mus musculus)
NCAM:pFyn (Y420) [plasma membrane] (Mus musculus)
NCAM:pFyn-Y420 [plasma membrane] (Mus musculus)
Other forms of this molecule
Fyn [cytosol]
phospho-MyrG-p-Y420-FYN-1 [plasma membrane]
pFyn(Y531) [cytosol]
phospho-p-S21,Y420-FYN [cytosol]
MyrG,p-Y420-Fyn [plasma membrane]
Inferred From
p-Y420-FYN [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 420
Coordinate
420
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_011241419.1
,
XP_006512603.1
,
NP_001116364.1
,
NP_032080.2
,
NP_001116365.1
,
XP_006512602.1
IntEnz
2.7.10.2
ZINC - Substances
FYN_MOUSE
ZINC target
P39688
Ensembl
ENSMUSP00000114188
,
ENSMUSG00000019843
,
ENSMUSP00000115233
,
ENSMUSP00000097547
,
ENSMUST00000135242
,
ENSMUST00000146287
,
ENSMUSP00000117111
,
ENSMUST00000099967
,
ENSMUSP00000057707
,
ENSMUST00000126486
,
ENSMUST00000063091
PRO
P39688
ZINC - Predictions - Purchasable
FYN_MOUSE
MGI
95602
PDB
3UF4
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9QUM4 SLAF1
0.82
15
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.591
3
UniProt:Q60749
3
Khdrbs1 [nucleoplasm]
(R-MMU-8848941)
phospho-Khdrbs1 [cytosol]
(R-MMU-8848995)
phospho-Khdrbs1 [nucleoplasm]
(R-MMU-8848970)
0.573
15
UniProt:P18052
1
PTPRA [plasma membrane]
(R-MMU-388755)
0.564
2
UniProt:O88890 SH21A
0.564
4
UniProt:P22682 Cbl
8
Cbl [cytosol]
(R-MMU-9680636)
p-Y-Cbl [cytosol]
(R-MMU-9680645)
phospho-p-Y-CBL [cytosol]
(R-MMU-8875457)
phospho-p-Y371-CBL [cytosol]
(R-MMU-182940)
phospho-p-Y371-CBL [plasma membrane]
(R-MMU-182923)
phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-MMU-8848826)
phospho-p-Y700,Y731,Y774-CBL [cytosol]
(R-MMU-912656)
CBL [cytosol]
(R-MMU-112199)
0.564
5
UniProt:Q9JIA7
1
SPHK2 [cytosol]
(R-MMU-428236)
0.544
2
UniProt:Q14332 FZD2
2
FZD2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140723)
FZD2 [plasma membrane]
(R-HSA-443945)
0.525
4
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.524
2
UniProt:O75051 PLXNA2
2
PLXNA2 [plasma membrane]
(R-HSA-396934)
p-Y-PLXNA2 [plasma membrane]
(R-HSA-419607)
0.499
3
UniProt:Q3U1F9
2
Pag1 [plasma membrane]
(R-MMU-180500)
phospho-Pag1 [plasma membrane]
(R-MMU-180494)
0.499
4
UniProt:Q9JJG6 TMM47
0.463
2
UniProt:P35570 Irs1
7
Irs1 [cytosol]
(R-RNO-1168867)
phospho-Irs1 [plasma membrane]
(R-RNO-2445090)
Irs1 [plasma membrane]
(R-RNO-2425392)
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-74769)
phospho-Irs1 [cytosol]
(R-RNO-74772)
phospho-Irs1 [plasma membrane]
(R-RNO-198366)
0.462
4
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