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SIRT1 [nucleoplasm]
Stable Identifier
R-MMU-427531
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q923E4
Locations in the PathwayBrowser for interactor UniProt:Q9WTL8 Arntl
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
SIRT1 binds to HSF1 (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
SIRT1 deacetylates HSF1 (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
Developmental Biology (Mus musculus)
MITF-M-regulated melanocyte development (Mus musculus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Mus musculus)
HINT1 binds MITF-M (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
SIRT1 deacetylates HINT1 dimer (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q923E4 Sirt1
Gene Names
Sirt1, Sir2l1
Chain
initiator methionine:, chain:2-737, chain:2-525
Reference Genes
BioGPS Gene:93759 Sirt1
KEGG:mmu:93759 Sirt1
Monarch:93759 Sirt1
NCBI Gene:93759 Sirt1
UCSC:Q923E4 Sirt1
Reference Transcript
RefSeq:NM_019812.3 Sirt1
Other Identifiers
10369738
111531_at
115059_at
1418640_at
17241582
4314274
4347990
4359481
4381779
4384877
4554421
4562215
4645704
4649340
4684892
4804148
5052557
5102287
5184515
5223304
5232810
5234347
5352978
5404804
5502505
5524143
5547537
93759
A_51_P141152
A_52_P358612
A_55_P2030428
A_55_P2598462
GE37604
GO:0000012
GO:0000122
GO:0000183
GO:0000720
GO:0000731
GO:0000785
GO:0000791
GO:0000792
GO:0000978
GO:0001525
GO:0001542
GO:0001650
GO:0001678
GO:0001934
GO:0001938
GO:0002039
GO:0002821
GO:0003013
GO:0003677
GO:0003713
GO:0003714
GO:0003824
GO:0005515
GO:0005634
GO:0005635
GO:0005637
GO:0005654
GO:0005677
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0006281
GO:0006325
GO:0006355
GO:0006476
GO:0006629
GO:0006642
GO:0006915
GO:0006974
GO:0006979
GO:0007179
GO:0007283
GO:0007346
GO:0007517
GO:0007623
GO:0008284
GO:0008630
GO:0009267
GO:0010460
GO:0010629
GO:0010659
GO:0010667
GO:0010824
GO:0010868
GO:0010875
GO:0010883
GO:0010906
GO:0010976
GO:0012501
GO:0014858
GO:0016239
GO:0016567
GO:0016605
GO:0016740
GO:0016787
GO:0016922
GO:0017136
GO:0019213
GO:0019899
GO:0019904
GO:0022414
GO:0030154
GO:0030163
GO:0030225
GO:0030424
GO:0030426
GO:0030512
GO:0031393
GO:0031507
GO:0031648
GO:0032007
GO:0032041
GO:0032071
GO:0032088
GO:0032436
GO:0032720
GO:0032868
GO:0032922
GO:0032991
GO:0033210
GO:0033553
GO:0033558
GO:0034391
GO:0034979
GO:0035098
GO:0035356
GO:0035358
GO:0035774
GO:0042127
GO:0042149
GO:0042311
GO:0042326
GO:0042393
GO:0042542
GO:0042595
GO:0042632
GO:0042771
GO:0042802
GO:0042981
GO:0043065
GO:0043066
GO:0043124
GO:0043161
GO:0043226
GO:0043398
GO:0043422
GO:0043425
GO:0043433
GO:0043518
GO:0043524
GO:0043536
GO:0044321
GO:0045348
GO:0045471
GO:0045599
GO:0045722
GO:0045739
GO:0045766
GO:0045786
GO:0045892
GO:0045944
GO:0046015
GO:0046628
GO:0046872
GO:0046969
GO:0046970
GO:0048511
GO:0048856
GO:0050872
GO:0051019
GO:0051152
GO:0051402
GO:0051658
GO:0051897
GO:0051898
GO:0055089
GO:0060090
GO:0060125
GO:0060766
GO:0060907
GO:0061051
GO:0061773
GO:0070301
GO:0070403
GO:0070857
GO:0070914
GO:0071356
GO:0071456
GO:0071479
GO:0090312
GO:0090335
GO:0090400
GO:0097009
GO:0106230
GO:0106231
GO:0140096
GO:0140110
GO:0140297
GO:0140861
GO:0140937
GO:0141050
GO:0141208
GO:0160011
GO:0160012
GO:1900181
GO:1901797
GO:1901984
GO:1902166
GO:1902176
GO:1902237
GO:1903427
GO:1904179
GO:1904639
GO:1904646
GO:1990254
GO:1990830
GO:1990841
GO:2000111
GO:2000270
GO:2000481
GO:2000614
GO:2000655
GO:2000757
GO:2000773
GO:2000774
GO:2000781
ILMN_2643159
mMC005543
Participates
as an output of
SIRT1 deacetylates HSF1 (Mus musculus)
as an input of
SIRT1 binds to HSF1 (Mus musculus)
as a component of
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Mus musculus)
as a member of
SIRT1,SIRT3 [nucleoplasm] (Mus musculus)
This entity regulates
Positively
HINT1 binds MITF-M
(Mus musculus)
Other forms of this molecule
Sirt1 [nucleoplasm]
Inferred From
SIRT1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_062786.1
ENSEMBL
ENSMUST00000120239
,
ENSMUST00000020257
,
ENSMUSP00000137565
,
ENSMUSP00000020257
,
ENSMUSP00000112595
,
ENSMUST00000177694
PRO
Q923E4
GlyGen
Q923E4
MGI
2135607
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.766
4
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.746
11
UniProt:O70343 Ppargc1a
7
monoSumo1-K183-Ppargc1a [nucleoplasm]
(R-MMU-3903008)
p-T177,S538-Ppargc1a [nucleoplasm]
(R-MMU-1605429)
p-T262,S265,T298-Ppargc1a [nucleoplasm]
(R-MMU-1605518)
phospho-Ppargc1a [nucleoplasm]
(R-MMU-1592224)
phospho-Ppargc1a [nucleoplasm]
(R-MMU-1592204)
Ppargc1a [nucleoplasm]
(R-MMU-556791)
Ppargc1a [nucleoplasm]
(R-MMU-442481)
0.729
6
UniProt:Q922Y0 DYRK3
0.639
7
UniProt:Q61214
1
DYRK1A [nucleoplasm]
(R-MMU-1362267)
0.61
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.602
4
UniProt:P22361 Hnf1a
1
hnf1-alpha/tcf1 [nucleoplasm]
(R-MMU-187289)
0.602
5
UniProt:P37238 Pparg
4
monoSumo1-K107,K395-Pparg [nucleoplasm]
(R-MMU-4717458)
Pparg [nucleoplasm]
(R-MMU-9841933)
phospho-Pparg [nucleoplasm]
(R-MMU-9842025)
Pparg [nucleoplasm]
(R-MMU-4717453)
0.589
2
UniProt:Q12778 FOXO1
5
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
p-S218-FOXO1 [nucleoplasm]
(R-HSA-5692651)
0.544
2
UniProt:Q9WTL8 Arntl
4
Arntl [nucleoplasm]
(R-MMU-9769624)
Bmal1 [nucleoplasm]
(R-MMU-9634872)
Arntl [cytosol]
(R-MMU-508660)
p-S-Arntl [nucleoplasm]
(R-MMU-508690)
0.527
5
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.524
2
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.524
2
UniProt:Q01094 E2F1
2
E2F1 [nucleoplasm]
(R-HSA-68639)
p-E2F1 [nucleoplasm]
(R-HSA-187911)
0.524
3
UniProt:Q60974 Ncor1
3
Ncor1 [cytosol]
(R-MMU-1253324)
Ncor1 [nucleoplasm]
(R-MMU-442459)
Ncor1 [nucleoplasm]
(R-MMU-442501)
0.524
3
UniProt:O35253 Smad7
2
Smad7 [cytosol]
(R-MMU-2161209)
Smad7 [nucleoplasm]
(R-MMU-2167887)
0.524
6
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