Reactome | G-protein gamma 2 subunit [plasma membrane]

G-protein gamma 2 subunit [plasma membrane]

Stable Identifier

R-MMU-428101

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Gng2, GBG2_MOUSE, Gng2

Locations in the PathwayBrowser

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Neuronal System (Mus musculus)

- Potassium Channels (Mus musculus)
  - Inwardly rectifying K+ channels (Mus musculus)
    - G protein gated Potassium channels (Mus musculus)
      - Activation of G protein gated Potassium channels (Mus musculus)
        
        Activation of GIRK/Kir3 Channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - Activation of kainate receptors upon glutamate binding (Mus musculus)
      - Presynaptic function of Kainate receptors (Mus musculus)
        
        Activation of GRIK3 homomer (Mus musculus)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        Kainate receptor-glutamate-Gprotein complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Mus musculus)
        
        Activation of GIRK/Kir3 Channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)

Transport of small molecules (Mus musculus)

- Aquaporin-mediated transport (Mus musculus)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Mus musculus)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Mus musculus)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Mus musculus)
        
        G-protein gamma subunit [plasma membrane] (Mus musculus)
        
        G-protein gamma 2 subunit [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P63213 Gng2

Gene Names

Gng2

Chain

initiator methionine:, chain:2-68, propeptide:69-71

Reference Genes

BioGPS Gene:14702 Gng2

ENSEMBL:ENSMUSG00000043004.14 Gng2

KEGG Gene (Mus musculus):14702 Gng2

Monarch:14702 Gng2

NCBI Gene:14702 Gng2

UCSC:P63213 Gng2

Reference Transcript

Other Identifiers

100418_at

10417787

134039_at

1418451_at

1418452_at

1428156_at

1428157_at

14702

163642_at

17303706

4312157

4334215

4377922

4499872

4505844

4815042

5042571

5052269

5056942

5081983

5320043

A_51_P220813

A_52_P263518

GE103043

GE35478

GO:0003824

GO:0003924

GO:0005834

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0016787

GO:0023052

GO:0031681

GO:0048144

ILMN_1214150

ILMN_3143604

Msa.10552.0_s_at

mMR028664

Participates

as a candidate of

G-protein gamma subunit [plasma membrane] (Mus musculus)

as a component of

Heterotrimeric G-protein G alphaq:beta1:gamma2 (inactive) [plasma membrane] (Mus musculus)

as a member of

G-protein gamma subunit [plasma membrane] (Mus musculus)

Other forms of this molecule

G-protein gamma 2 subunit [cytosol]

Inferred From

GNG2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001272839.1, NP_001272837.1, NP_001033726.1, NP_034445.1, NP_001272840.1, NP_001272838.1

Ensembl

ENSMUST00000161247, ENSMUST00000162425, ENSMUST00000159073, ENSMUST00000160013, ENSMUSP00000125697, ENSMUSG00000043004, ENSMUSP00000055256, ENSMUST00000159028, ENSMUSP00000124725, ENSMUST00000055100, ENSMUSP00000124153, ENSMUSP00000125141, ENSMUSP00000125000

PRO

P63213

MGI

102705

PDB

8IHF, 7PIV, 8IHI, 7Y15, 6RMV, 8IHB, 7Y12, 8IHH, 8IHJ

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