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phospho-p-Y-SYK [plasma membrane]
Stable Identifier
R-MMU-429432
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
P48025
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
phospho-p-Y-SYK [plasma membrane] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin-2 signaling (Mus musculus)
SYK is a substrate for JAK1 (Mus musculus)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Mus musculus)
phospho-p-Y-SYK [plasma membrane] (Mus musculus)
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
phospho-p-Y-SYK [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P48025 Syk
Gene Names
Syk, ptk72, Sykb
Chain
chain:1-629
Reference Genes
BioGPS Gene:20963 Syk
KEGG:mmu:20963 Syk
Monarch:20963 Syk
NCBI Gene:20963 Syk
UCSC:P48025 Syk
Reference Transcript
RefSeq:NM_011518.2 Syk
RefSeq:NM_001198977.1 Syk
RefSeq:XM_006516895.3 Syk
Other Identifiers
100425_at
100426_s_at
10405216
1418261_at
1418262_at
1425797_a_at
1457239_at
17287381
20963
4364453
4445750
4461813
4476939
4520961
4579585
4647877
4654953
4665178
4736195
4868775
4870615
4885339
4950455
5060677
5103375
5150242
5191797
5211223
5236290
5292099
5349414
5413474
5430379
5583840
A_51_P444934
A_55_P1962946
A_55_P2172867
A_55_P2718663
A_66_P138936
GE36166
GO:0001525
GO:0001775
GO:0001784
GO:0001819
GO:0001820
GO:0001945
GO:0002092
GO:0002223
GO:0002250
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0002684
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0007155
GO:0007159
GO:0007166
GO:0007167
GO:0007169
GO:0007186
GO:0007229
GO:0010543
GO:0010803
GO:0016020
GO:0016170
GO:0016192
GO:0016301
GO:0016740
GO:0018108
GO:0019370
GO:0019722
GO:0019815
GO:0019901
GO:0019902
GO:0019904
GO:0030154
GO:0030183
GO:0030593
GO:0031334
GO:0031410
GO:0031623
GO:0031625
GO:0032009
GO:0032481
GO:0032725
GO:0032733
GO:0032735
GO:0032752
GO:0032753
GO:0032755
GO:0032757
GO:0032760
GO:0032765
GO:0032928
GO:0032930
GO:0032991
GO:0033630
GO:0035325
GO:0035556
GO:0038063
GO:0038156
GO:0042101
GO:0042169
GO:0042492
GO:0042742
GO:0043226
GO:0043274
GO:0043303
GO:0043306
GO:0043313
GO:0043366
GO:0043410
GO:0045087
GO:0045335
GO:0045579
GO:0045588
GO:0045780
GO:0046638
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050731
GO:0050764
GO:0050776
GO:0050850
GO:0050853
GO:0051649
GO:0051712
GO:0070372
GO:0071226
GO:0071396
GO:0071404
GO:0071639
GO:0090237
GO:0090330
GO:0097110
GO:0097242
GO:0098542
GO:0120162
GO:0140096
GO:1904263
GO:1904646
GO:1990858
ILMN_1252460
mMC017992
z49877_s_at
Participates
as a component of
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Mus musculus)
Other forms of this molecule
p-Syk [cytosol]
phospho-p-Y-SYK [cytosol]
Syk [cytosol]
p-Y348,Y352,Y525,Y526-Syk [cytosol]
phospho-p-6Y-SYK [cytosol]
phospho-p-Y348-SYK [cytosol]
SYK [cytosol]
Inferred From
p-Y-SYK [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001185906.1
,
XP_006516958.1
,
NP_035648.2
ENSEMBL
ENSMUST00000120135
,
ENSMUST00000055087
,
ENSMUSP00000060828
,
ENSMUSP00000113852
IntEnz
2.7.10.2
PRO
P48025
MGI
99515
PDB
2LCT
,
2MC1
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42227 Stat3
13
phospho-Stat3 [nucleoplasm]
(R-MMU-1112554)
phospho-Stat3 [cytosol]
(R-MMU-914048)
Stat3 [cytosol]
(R-MMU-539044)
phospho-Stat3 [cytosol]
(R-MMU-8983130)
Stat3 [cytosol]
(R-MMU-914084)
p-Y705-Stat3 [cytosol]
(R-MMU-914034)
p(Y705)-Stat3 [nucleoplasm]
(R-MMU-2730582)
phospho-Stat3 [cytosol]
(R-MMU-539048)
phospho-Stat3 [nucleoplasm]
(R-MMU-9027589)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701429)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701435)
phospho-Stat3 [cytosol]
(R-MMU-8982823)
phospho-Stat3 [nucleoplasm]
(R-MMU-8983188)
0.611
5
UniProt:Q64693 OBF1
0.544
2
IntAct:EBI-15720745 DPITAM
0.544
2
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.524
2
UniProt:P08487 PLCG1
0.462
4
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