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Arhgef7 [cytosol]
Stable Identifier
R-MMU-430346
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
ARHGEF7, Q9ES28
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
Ephrin signaling (Mus musculus)
GIT1 binds bPIX (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
PAK binds RAC and bPIX (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
PAKs autophosphorylate (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Mus musculus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRAGE signals death through JNK (Mus musculus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
GEFs [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
GEFs activate RhoA,B,C (Mus musculus)
GEFs [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
EGFR downregulation (Mus musculus)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
CDC42:GTP binds CBL:Beta-Pix (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Mus musculus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 GEFs activate RAC1 (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
RHOA GTPase cycle (Mus musculus)
RHOA GEFs activate RHOA (Mus musculus)
RHOA GEFs [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
RHOQ GTPase cycle (Mus musculus)
RHOQ binds effectors at the plasma membrane (Mus musculus)
RHOQ effectors [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Mus musculus)
RHOQ effectors [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
RHOU GTPase cycle (Mus musculus)
RHOU binds effectors at the plasma membrane (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
RHOU:GTP:RHOU effectors [plasma membrane] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
RHOV GTPase cycle (Mus musculus)
RHOV binds effectors at the plasma membrane (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
RHOV:GTP:RHOV effectors [plasma membrane] (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
Arhgef7 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9ES28
Gene Names
Arhgef7
Reference Genes
BioGPS Gene:54126 ARHGEF7
ENSEMBL:ENSMUSG00000031511
KEGG:mmu:54126 ARHGEF7
Monarch:54126 ARHGEF7
NCBI Gene:54126 ARHGEF7
UCSC:Q9ES28 ARHGEF7
Reference Transcript
RefSeq:XM_006508843.3 ARHGEF7
RefSeq:XM_006508841.2 ARHGEF7
RefSeq:NM_017402.4 ARHGEF7
RefSeq:NM_001113517.1 ARHGEF7
RefSeq:XM_006508844.2 ARHGEF7
RefSeq:NM_001113518.1 ARHGEF7
Participates
as a candidate of
RHOA GEFs [cytosol] (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
RHOQ effectors [cytosol] (Mus musculus)
CDC42 effectors [cytosol] (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
RHOJ effectors [cytosol] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
as an input of
GIT1 binds bPIX (Mus musculus)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Mus musculus)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
Beta-Pix:CDC42:GTP [cytosol] (Mus musculus)
as a member of
GEFs [cytosol] (Mus musculus)
Inferred From
ARHGEF7 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSMUST00000110909
,
ENSMUSP00000106534
,
ENSMUST00000098938
,
ENSMUSG00000031511
,
ENSMUSP00000096538
PRO
Q9ES28
GlyGen
Q9ES28
MGI
1860493
PDB
6JMT
,
2ESW
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HBI1 PARVB
1
PARVB [cytosol]
(R-HSA-446016)
0.619
10
UniProt:Q68FF6 Git1
4
p-Y392-Git1 [cytosol]
(R-MMU-3928429)
Git1 [cytosol]
(R-MMU-3928400)
phospho-Git1 [cytosol]
(R-MMU-3928463)
Git1 [cytosol]
(R-MMU-430326)
0.564
2
UniProt:Q9QX74-4 SHANK2
0.558
3
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.499
2
UniProt:Q9Z272 Git1
3
phospho-Git1 [cytosol]
(R-RNO-3928463)
Git1 [cytosol]
(R-RNO-9619771)
Git1 [cytosol]
(R-RNO-430326)
0.499
2
UniProt:P26433
1
SLC9A3 [plasma membrane]
(R-RNO-425992)
0.462
2
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