Syk binds Vav2

Stable Identifier
R-MMU-442289
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Syk binds Vav2
Constructs containing the C-terminal SH3-SH2-SH3 domain of Vav2 interact with Syk. An SH2-inactivating point mutation (R688Q) abolishes the interaction.
Literature References
PubMed ID Title Journal Year
11262396 Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte

Charvet, C, Tartare-Deckert, S, Monthouel, MN, Deckert, M, Altman, A, Bernard, A, Foucault, I, Van Obberghen, E

J Biol Chem 2001
Participants
Input
Output
Orthologous Events
p-Y348-SYK binds VAV family (Homo sapiens)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-09-24)
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