Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Frs2 [cytosol]
Stable Identifier
R-MMU-443125
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
Frs2-mediated activation (Mus musculus)
FRS2 binds to active TrkA receptor (Mus musculus)
Active TrkA receptor:FRS2 complex [endosome membrane] (Mus musculus)
Frs2 [cytosol] (Mus musculus)
Frs2 [cytosol] (Mus musculus)
FRS2 is phosphorylated by active TrkA receptor (Mus musculus)
Active TrkA receptor:FRS2 complex [endosome membrane] (Mus musculus)
Frs2 [cytosol] (Mus musculus)
Signaling by NTRK2 (TRKB) (Mus musculus)
Activated NTRK2 signals through FRS2 and FRS3 (Mus musculus)
Activated NTRK2 binds FRS2 (Mus musculus)
BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Mus musculus)
Frs2 [cytosol] (Mus musculus)
Frs2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8C180 Frs2
Gene Names
Frs2, Frs2a
Chain
initiator methionine:1, chain:2-508
Reference Genes
BioGPS Gene:327826 Frs2
KEGG:mmu:327826 Frs2
Monarch:327826 Frs2
NCBI Gene:327826 Frs2
UCSC:Q8C180 Frs2
Reference Transcript
RefSeq:NM_177798.4 Frs2
RefSeq:NM_001408283.1 Frs2
RefSeq:NM_001408294.1 Frs2
RefSeq:NM_001408282.1 Frs2
RefSeq:NM_001408293.1 Frs2
RefSeq:NM_001408286.1 Frs2
RefSeq:NM_001408295.1 Frs2
RefSeq:NM_001408285.1 Frs2
RefSeq:NM_001408291.1 Frs2
RefSeq:NM_001408284.1 Frs2
RefSeq:NM_001408289.1 Frs2
RefSeq:NM_001408297.1 Frs2
RefSeq:NM_001408296.1 Frs2
RefSeq:NM_001408288.1 Frs2
RefSeq:NM_001408287.1 Frs2
RefSeq:NM_001408290.1 Frs2
RefSeq:NM_001408292.1 Frs2
Other Identifiers
10372618
115218_at
1437891_at
1444162_at
17245188
327826
4341790
4348189
4361013
4428139
4477674
4537266
4587272
4628652
4738598
4755262
4766025
4794121
4814497
4878800
4997747
5006977
5007095
5050124
5351947
5363798
5380057
5410462
5410800
5521119
5604305
A_51_P413991
A_52_P105138
A_52_P105147
A_55_P2935763
A_66_P114243
GE1502889
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007405
GO:0008543
GO:0008595
GO:0016020
GO:0030900
GO:0042981
GO:0043410
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:2000726
ILMN_1221488
ILMN_1226775
ILMN_2993711
mMC016758
Participates
as a component of
BDNF,NTF4:p-5Y-Ntrk2:Frs2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Mus musculus)
Active TrkA receptor:FRS2 complex [endosome membrane] (Mus musculus)
as an input of
Activated NTRK2 binds FRS2 (Mus musculus)
FRS2 binds to active TrkA receptor (Mus musculus)
Other forms of this molecule
phospho-Frs2 [plasma membrane]
Frs2 [plasma membrane]
phospho-Frs2 [plasma membrane]
phospho-Frs2 [cytosol]
p-Y-Frs2 [cytosol]
Inferred From
FRS2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001395224.1
,
NP_001395214.1
,
NP_001395225.1
,
NP_001395213.1
,
NP_001395226.1
,
NP_001395216.1
,
NP_001395215.1
,
NP_001395219.1
,
NP_001395217.1
,
NP_001395218.1
,
NP_001395221.1
,
NP_001395220.1
,
NP_808466.1
,
NP_001395223.1
,
NP_001395212.1
,
NP_001395211.1
,
NP_001395222.1
ENSEMBL
ENSMUSP00000020381
,
ENSMUST00000020381
,
ENSMUSG00000020170
PRO
Q8C180
MGI
1100860
GlyGen
Q8C180
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
3
Grb2 [cytosol]
(R-MMU-74686)
Grb2 [plasma membrane]
(R-MMU-202993)
Grb2 [cytosol]
(R-MMU-443287)
0.527
5
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text