NrCAM binds synapse-associated proteins

Stable Identifier
R-MMU-443767
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
NrCAM binds synapse-associated proteins

NrCAM is the only mammalian L1CAM family member containing a consensus PDZ binding motif. NrCAM interacts with the PDZ domain containing proteins SAP-102, SAP-95 and SAP-97 and recruits them to the cell membrane. These SAP family members are colocalized with NrCAM in photoreceptor cells of the mammalian retina.

Literature References
PubMed ID Title Journal Year
15992371 Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule

Davey, F, Hill, M, Falk, J, Sans, N, Gunn-Moore, FJ

J Neurochem 2005
16882004 The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97

Dirks, P, Thomas, U, Montag, D

Eur J Neurosci 2006
Participants
Orthologous Events
Authored
Reviewed
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