Reactome | MAPK10 [cytosol]

MAPK10 [cytosol]

Stable Identifier

R-MMU-450352

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q61831

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
        
        MAPK8,9,10 [cytosol] (Mus musculus)
        
        MAPK10 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q61831

Reference Genes

BioGPS Gene:26414

ENSEMBL:ENSMUSG00000046709

KEGG Gene (Mus musculus):26414

Monarch:26414

NCBI Gene:26414

UCSC:Q61831

Reference Transcript

Participates

as a member of

MAPK8,9,10 [cytosol] (Mus musculus)

Other forms of this molecule

phospho-p-T221,Y223-MAPK10 [cytosol]

phospho-p-T221,Y223-MAPK10 [nucleoplasm]

Inferred From

MAPK10 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017176379.1, NP_001297615.1, XP_017176380.1

PRO

Q61831

MGI

1346863

Cite Us!