Phosphorylation of Khsrp by p38

Stable Identifier
R-MMU-451204
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of Khsrp by p38
Activated p38 alpha and beta phoshorylate Khsrp at threonine692. The phosphorylation interferes with the ability of Khsrp to bind RNA.
Literature References
PubMed ID Title Journal Year
16364914 p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

Karin, M, Briata, P, Ponassi, M, Forcales, SV, Gherzi, R, Chen, CY, Puri, PL, Corte, G

Mol Cell 2005
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of phospho-MAPK p38 alpha/beta [cytosol]

Physical Entity
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MAP kinase p38 phosphorylates KSRP (Homo sapiens)
Authored
May, B  (2009-12-17)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-31)
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