Vangl2 is phosphorylated in response to Wnt5a

Stable Identifier
R-MMU-4551572
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Vangl2 is phosphorylated in response to Wnt5a

Vangl2 is multiply phosphorylated on two clusters of serine and threonine residues in response to Wnt5a. Phosphorylation at serine 5, 82 and 84 appear to be required for more extensive phosphorylation at other positions. Overexpression of CK1delta promotes Vangl2 phosphorylation in CHO cells suggesting it may the activating kinase (Gao et al, 2011).

Literature References
PubMed ID Title Journal Year
21316585 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Song, H, Yang, Y, Garrett, L, Robinson, J, Economides, AN, Minami, Y, Bishop, K, English, MA, Gao, B, Sood, R, Andre, P, Elliot, G

Dev. Cell 2011
Participants
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Orthologous Events
Authored
Reviewed
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