Reactome | Hdac2 [nucleoplasm]

Hdac2 [nucleoplasm]

Stable Identifier

R-MMU-4615958

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

monoSUMO1-K462-HDAC2, P70288

Locations in the PathwayBrowser for interactor UniProt:Q6ZQ88

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Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - SUMOylation (Mus musculus)
    - SUMO E3 ligases SUMOylate target proteins (Mus musculus)
      - SUMOylation of chromatin organization proteins (Mus musculus)
        
        SUMOylation of HDAC2 with SUMO1 (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P70288 Hdac2

Gene Names

Hdac2, Yy1bp

Chain

chain:1-488

Reference Genes

BioGPS Gene:15182 Hdac2

KEGG Gene (Mus musculus):15182 Hdac2

Monarch:15182 Hdac2

NCBI Gene:15182 Hdac2

UCSC:P70288 Hdac2

Reference Transcript

RefSeq:NM_008229.2 Hdac2

Participates

as an output of

SUMOylation of HDAC2 with SUMO1 (Mus musculus)

Other forms of this molecule

Hdac2 [nucleoplasm]

Inferred From

monoSUMO1-K462-HDAC2 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 462 (in Homo sapiens)

Coordinate

462

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_032255.2

IntEnz

3.5.1.98

PRO

P70288

MGI

1097691

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60520 Sin3a	3	Sin3a [nucleoplasm] (R-MMU-4086071) Sin3a [nucleoplasm] (R-MMU-573326) Sin3a [nucleoplasm] (R-MMU-351657)	0.784	7
UniProt:Q9R190 Mta2	1	Mta2 [nucleoplasm] (R-MMU-5096453)	0.708	7
UniProt:O09106 Hdac1	2	Hdac1 [nucleoplasm] (R-MMU-4616030) Hdac1 [nucleoplasm] (R-MMU-573340)	0.643	5
UniProt:Q6ZQ88	1	KDM1A [nucleoplasm] (R-MMU-996769)	0.623	4
UniProt:Q62233 SIX3			0.544	2
UniProt:E9QAG8	14	Znf431 [nucleoplasm] (R-MMU-2586613-20) Znf431 [nucleoplasm] (R-MMU-1027421-20) Znf431 [nucleoplasm] (R-MMU-1247531-20) Znf431 [nucleoplasm] (R-MMU-1247542-20) Znf431 [nucleoplasm] (R-MMU-2127573-20) Znf431 [nucleoplasm] (R-MMU-2127569-20) Znf431 [nucleoplasm] (R-MMU-3323094-20) Znf431 [nucleoplasm] (R-MMU-2127597-20) Znf431 [nucleoplasm] (R-MMU-975011-20) Znf431 [nucleoplasm] (R-MMU-975012-20) Znf431 [nucleoplasm] (R-MMU-1973899-20) Znf431 [nucleoplasm] (R-MMU-1247871-20) Znf431 [nucleoplasm] (R-MMU-1247857-20) Znf431 [nucleoplasm] (R-MMU-2454142-20)	0.524	3
UniProt:P11103	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-MMU-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-MMU-4551686) PAR-PARP1 [nucleoplasm] (R-MMU-5651713) PARP1 [nucleoplasm] (R-MMU-201568)	0.499	3
UniProt:Q3TKT4 Smarca4	2	SMARCA4 [nucleoplasm] (R-MMU-201686) Smarca4 [nucleoplasm] (R-MMU-9727480)	0.499	4
UniProt:Q8C796 RCOR2			0.499	2
UniProt:O35846 O35846			0.463	3
UniProt:O54864	1	SUV39H1 [nucleoplasm] (R-MMU-427517)	0.462	2
UniProt:Q60I23 Q60I23			0.462	2
UniProt:Q6AXH7 Q6AXH7			0.462	2
UniProt:P48432 Sox2	2	Sox2 [nucleoplasm] (R-MMU-3246072) Sox2 [nucleoplasm] (R-MMU-452271)	0.462	2

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