Reactome | Pparg [nucleoplasm]

Pparg [nucleoplasm]

Stable Identifier

R-MMU-4717453

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor gamma, PPARG_MOUSE

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- Epigenetic regulation of gene expression (Mus musculus)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Mus musculus)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Mus musculus)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Mus musculus)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Mus musculus)
        
        ABL1 binds PPARG2 (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        p-Y226,Y393-ABL1:PPARG2 [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        ABL1 phosphorylates PPARG2 (Mus musculus)
        
        p-Y226,Y393-ABL1:PPARG2 [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        RXRA binds ligands (Mus musculus)
        
        PPARG ligands:PPARG:RXRA ligands:RXRA:Corepressors:adipogenesis genes:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:ACSL1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:ADIPOQ gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:AGPAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:ANGPTL4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:CD36 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:CEBPA gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:CIDEC gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:DGAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:FABP4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:LIPE gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:LPIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:LPL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:MGLL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PDK4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PEX11A gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PLIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PLIN2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PLIN4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PNPLA2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PPARG gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:SCD gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        PPARG ligands:PPARG:RXRA:Corepressors:adipogenesis genes:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:ACSL1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:ADIPOQ gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:AGPAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:ANGPTL4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:CD36 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:CEBPA gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:CIDEC gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:DGAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:FABP4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:LIPE gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:LPIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:LPL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:MGLL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PDK4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PEX11A gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PNPLA2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PPARG gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:SCD gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA [nucleoplasm] (Mus musculus)
        
        PPARG:RXRA Heterodimer [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Nuclear Receptor transcription pathway (Mus musculus)
      - Formation of NR-MED1 Coactivator Complex (Mus musculus)
        
        NR [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        NR-MED1 Coactivator Complex [nucleoplasm] (Mus musculus)
        
        NR [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
      - Formation of NR-NCOR Corepressor Complex (Mus musculus)
        
        NR [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)
        
        NR-NCOR CoRepressor Complex [nucleoplasm] (Mus musculus)
        
        NR [nucleoplasm] (Mus musculus)
        
        Pparg [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P37238 Pparg

Gene Names

Pparg, Nr1c3

Chain

chain:1-505

Reference Genes

BioGPS Gene:19016 Pparg

KEGG Gene (Mus musculus):19016 Pparg

Monarch:19016 Pparg

NCBI Gene:19016 Pparg

Reference Transcript

Participates

as an input of

as a component of

as a member of

NR [nucleoplasm] (Mus musculus)

Other forms of this molecule

monoSumo1-K107,K395-Pparg [nucleoplasm]

Pparg [nucleoplasm]

phospho-Pparg [nucleoplasm]

Inferred From

PPARG2 [nucleoplasm] (Homo sapiens)

PPARG [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_017176944.1, XP_006505806.1, NP_001295283.1, NP_001295281.1, NP_001120802.1, XP_011239554.1, NP_035276.2

ZINC - Investigational

PPARG_MOUSE

ZINC - Metabolites

PPARG_MOUSE

ZINC - World Drugs

PPARG_MOUSE

ZINC - FDA approved

PPARG_MOUSE

ZINC - Substances

PPARG_MOUSE

ZINC - Biogenic

PPARG_MOUSE

ZINC target

P37238

PRO

P37238

MGI

97747

ZINC - Predictions - Purchasable

PPARG_MOUSE

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q923E4 Sirt1	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.589	2

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