Pias1 Sumoylates Nr2c1 (Tr2)

Stable Identifier
R-MMU-4717491
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pias1 Sumoylates Nr2c1 (Tr2)
Pias1 Sumoylates Nr2c1 (Tr2) with Sumo1 at lysine-238 (Park et al. 2007, Gupta et al. 2008). Unsumoylated Nr2c1 is localized to PML bodies in the nucleus and coactivates Oct4-activated transcription at promoters. Sumoylation causes Nr2c1 to be released from PML bodies and to act as a corepressor.
Literature References
PubMed ID Title Journal Year
17187077 SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells

Park, SW, Hu, X, Gupta, P, Lin, YP, Ha, SG, Wei, LN

Nat. Struct. Mol. Biol. 2007
18682553 Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression

Gupta, P, Ho, PC, Huq, MM, Ha, SG, Park, SW, Khan, AA, Tsai, NP, Wei, LN

Proc. Natl. Acad. Sci. U.S.A. 2008
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Pias1 [nucleoplasm]

Physical Entity
Pias1 [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1 SUMOylates NR2C1 (TR2) (Homo sapiens)
Authored
May, B  (2013-10-11)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-18)
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