Reactome | Rif1 [nucleoplasm]

Rif1 [nucleoplasm]

Stable Identifier

R-MMU-480742

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

RIF1, Q6PR54

Locations in the PathwayBrowser

Expand all

DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - Nonhomologous End-Joining (NHEJ) (Mus musculus)
    - Activated ATM phosphorylates DCLRE1C (Mus musculus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Mus musculus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Mus musculus)
        
        Rif1 [nucleoplasm] (Mus musculus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Mus musculus)
        
        Rif1 [nucleoplasm] (Mus musculus)
    - Association of Ku heterodimer with ends of DNA double-strand break (Mus musculus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Mus musculus)
        
        Rif1 [nucleoplasm] (Mus musculus)
      - Rif1 [nucleoplasm] (Mus musculus)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Mus musculus)
        
        Rif1 [nucleoplasm] (Mus musculus)
      - Rif1 [nucleoplasm] (Mus musculus)
    - TP53BP1 recruits DCLRE1C to ATM (Mus musculus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Mus musculus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Mus musculus)
        
        Rif1 [nucleoplasm] (Mus musculus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Mus musculus)
        
        Rif1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6PR54

Gene Names

Rif1

Reference Genes

BioGPS Gene:51869 Rif1

ENSEMBL:ENSMUSG00000036202

ENSEMBL:ENSMUSG00000036202.17 Rif1

KEGG Gene (Mus musculus):51869 Rif1

Monarch:51869 Rif1

NCBI Gene:51869 Rif1

UCSC:Q6PR54 Rif1

Reference Transcript

Other Identifiers

10472058

107613_at

107614_at

131411_at

1429490_at

1429491_s_at

1437179_at

1442939_at

17370745

4358256

4385030

4410157

4410194

4427270

4458044

4478448

4496469

4502163

4546683

4627373

4663251

4677462

4683133

4764094

4770957

4797632

4858370

4966370

4984406

4986609

5010723

5037048

5044581

5165853

5182025

51869

5190241

5248802

5267638

5414756

5422174

5423458

5427916

5452182

5464430

5468056

5472876

5478427

5503650

5510593

5565021

A_51_P305693

A_55_P2015964

GE1415114

GE1539822

GO:0000122

GO:0000723

GO:0000781

GO:0000785

GO:0000793

GO:0001939

GO:0001940

GO:0002376

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005819

GO:0005856

GO:0005886

GO:0006281

GO:0006310

GO:0006325

GO:0006351

GO:0006355

GO:0006974

GO:0007049

GO:0031509

GO:0031965

GO:0032200

GO:0035019

GO:0035861

GO:0043226

GO:0043247

GO:0045814

GO:0045830

GO:0048856

GO:0051233

GO:0140445

GO:1990830

GO:2000042

GO:2001034

ILMN_1243796

ILMN_2668576

ILMN_3007813

c76985_rc_at

mMC021064

Participates

as an output of

Association of Ku heterodimer with ends of DNA double-strand break (Mus musculus)

as an input of

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Mus musculus)

Inferred From

RIF1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_011237438.1, XP_006498240.1, NP_780447.4

Ensembl

ENSMUST00000112693, ENSMUSP00000108313, ENSMUSG00000036202

PRO

Q6PR54

MGI

1098622

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q80Z64 Nanog	1	Nanog [nucleoplasm] (R-MMU-9833222)	0.612	5
UniProt:Q61066	1	Nr0b1 [nucleoplasm] (R-MMU-3008626)	0.564	2

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